31698-14-3

• 常用中文名：安西他滨
• 常用英文名：Ancitabine
• CAS号：31698-14-3
• 分子式：C₉H₁₁N₃O₄
• 分子量：225.20100
• 相关类别： 原料药 抗肿瘤药 抗代谢类抗肿瘤药
• 发布时间：2018-05-30 08:00:00
• 更新时间：2024-01-06 19:09:08
• Ancitabine 是一类抗白血病活性分子。

名称

• 中文名: 安西他滨
• 英文名: ancitabine
• 中文别名: 环胞啶; 1,4-双(双氰)环己烷; 1,4 -双(双氰)环己烷
• 英文别名: anhydroarac; CYCLOCYTIDINE HCL; Cyclocytidine; Ancitabine; 2,2'-(1,4-CYCLOHEXANEDIYLIDENE)-BISPROPANEDINITRILE; 2,2'-ANHYDRO-L-CYTIDINE; 2,2'-anhydrocytidine; anhydrocytidine; cyclocitidine; ancytabine

物化性质

• 密度: 2.01 g/cm3
• 沸点: 422.2ºCat 760 mmHg
• 熔点: 269-270ºC
• 分子式: C₉H₁₁N₃O₄
• 分子量: 225.20100
• 精确质量: 225.07500
• PSA: 100.59000
• 折射率: 1.5100 (estimate)
• 储存条件: −20°C

生物活性

• 描述: Ancitabine 是一类抗白血病活性分子。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Z Rao, et al. Study on the Synthesis of Cytarabine Hydrochloride and its Intermediate Ancitabine Hydrochloride. Fine Chemical Intermediates, 2013

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LV2610000 CAS REGISTRY NUMBER : 31698-14-3 LAST UPDATED : 199512 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C9-H11-N3-O4 MOLECULAR WEIGHT : 225.23 WISWESSER LINE NOTATION : T B556 AN CO GO INYTT&J D1Q EQ JUM HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >7 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1700 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 820 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3400 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1600 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4050 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2745 mg/kg/9W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Leukocyte DOSE/DURATION : 700 ug/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,1235,1974

安全

• WGK德国: 2
• RTECS号: LV2615000

合成路线

50896-83-8 ~% 31698-14-3

文献：Journal of Organic Chemistry, , vol. 39, # 15 p. 2182 - 2186

10323-20-3 ~% 31698-14-3

文献：Journal of Organic Chemistry, , vol. 41, # 10 p. 1828 - 1831

532-20-7 ~% 31698-14-3

文献：Journal of Organic Chemistry, , vol. 38, # 3 p. 593 - 598

65-46-3 ~% 31698-14-3

文献：Journal of Organic Chemistry, , vol. 37, p. 284 - 288

27963-98-0 58311-73-2 ~% 31698-14-3

文献：Journal of Organic Chemistry, , vol. 41, # 10 p. 1828 - 1831

55628-10-9 ~% 31698-14-3

文献：Bulletin of the Chemical Society of Japan, , vol. 48, p. 505 - 507

10212-17-6 ~% 31698-14-3

文献：The Journal of organic chemistry, , vol. 32, # 5 p. 1462 - 1471

74580-91-9 ~% 31698-14-3 147-94-4

文献：Journal of Medicinal Chemistry, , vol. 23, # 10 p. 1088 - 1094

1070-71-9 27963-98-0 ~% 31698-14-3

文献：Journal of Organic Chemistry, , vol. 38, # 3 p. 593 - 598

上下游产品

上游产品  7
10323-20-3 65-46-3 27963-98-0 58311-73-2
55628-10-9 74580-91-9 1070-71-9
下游产品  3
10212-20-1 147-94-4 80791-93-1