134-80-5

• 常用中文名：盐酸安非拉酮
• 常用英文名：Diethylpropion Hydrochloride
• CAS号：134-80-5
• 分子式：C₁₃H₂₀ClNO
• 分子量：241.757
• 相关类别： 原料药 神经系统用药 其它神经系统用药
• 发布时间：2018-03-18 08:00:00
• 更新时间：2024-01-06 13:53:44

名称

• 中文名: 盐酸安非拉酮
• 英文名: diethylpropion hydrochloride
• 中文别名: 安非拉酮盐酸盐; 2-(二乙基氨基)-1-苯基-1-丙酮盐酸盐
• 英文别名: 1-Propanone, 2-(diethylamino)-1-phenyl-, hydrochloride (1:1); Prefamone; Keramik; Keramin; Diethylpropione hydrochloride; 2-(diéthylamino)-1-phénylpropan-1-one chlorhydrate; 2-(Diethylamino)-1-phenyl-1-propanone hydrochloride (1:1); 2-(Diethylamino)-1-phenylpropan-1-onhydrochlorid; Diethylpropion Hydrochloride; Regenon; ANOREX; Danylen; Frekentine; Tylinal; 2-(diethylamino)-1-phenylpropan-1-one,hydrochloride; EINECS 205-156-5; 2-(diethylamino)-1-phenylpropan-1-one hydrochloride; 2-Diethylaminopropiophenone Hydrochloride; a-Benzoyltriethylamine Hydrochloride; Anfamon; 2-(Diethylamino)-1-phenylpropan-1-one hydrochloride (1:1); UNII:19V2PL39NG; Amfepramone HCL; Magrene; Modulor; Parabolin

物化性质

• 密度: 0.972g/cm3
• 沸点: 292ºC at 760mmHg
• 熔点: 180-181ºC
• 分子式: C₁₃H₂₀ClNO
• 分子量: 241.757
• 闪点: 95.4ºC
• 精确质量: 241.123337
• PSA: 20.31000
• LogP: 3.40160
• 蒸汽压: 0.00189mmHg at 25°C
• 储存条件: Controlled Substance, -20°C Freezer
• 分子结构:

  1、 摩尔折射率：63.12

  2、 摩尔体积（cm³/mol）：211.1

  3、 等张比容（90.2K）：514.4

  4、 表面张力（dyne/cm）：35.2

  5、 极化率（10-24cm3）：25.02

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:2

  4.可旋转化学键数量:5

  5.互变异构体数量:2

  6.拓扑分子极性表面积20.3

  7.重原子数量:16

  8.表面电荷:0

  9.复杂度:193

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UH0360000 CHEMICAL NAME : Propiophenone, 2-(diethylamino)-, hydrochloride CAS REGISTRY NUMBER : 134-80-5 LAST UPDATED : 199606 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C13-H19-N-O.Cl-H MOLECULAR WEIGHT : 241.79 WISWESSER LINE NOTATION : 2N2&Y1&VR &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 17,373,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 139 mg/kg TOXIC EFFECTS : Behavioral - excitement REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 17,121,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 385 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 17,373,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 17,373,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - excitement Skin and Appendages - hair REFERENCE : APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 4,37,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 17,182,1960

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302 + H312 + H332
• 警示性声明: P261-P280-P301 + P312 + P330
• 危害码 (欧洲): F,T
• 风险声明 (欧洲): 11-23/24/25-39/23/24/25-20/21/22
• 安全声明 (欧洲): 7-16-36/37-45-36
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol, solution
• 海关编码: 2922399090

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海关

海关编码	2922399090
中文概述	2922399090 其他氨基醛、氨基酮及其盐（包括氨基醌及其盐，但含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%