133-17-5

• 常用中文名：邻碘马尿酸钠
• 常用英文名：o-Iodohippurate sodium
• CAS号：133-17-5
• 分子式：C₉H₇INNaO₃
• 分子量：327.05100
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-08-17 12:24:31
• 更新时间：2024-01-11 11:16:26
• o-Iodohippurate sodium is an analogue of p-aminohippuric acid for the determination of effective renal plasma flow. Labelled OIH has a significantly higher clearance than other radiopharmaceutical yet developed and is eminently suitable for renography. It is eliminated mainly by tubular secretion. In patients with normally functioning kidneys, 85% of the OIH may be found in the urine 30 minutes after intravenous injection.

名称

• 中文名: 邻碘马尿酸钠
• 英文名: sodium o-iodohippurate
• 英文别名: hippuran; jodairol; iodohippura; medopaque; Sodium iodohippurate; EINECS 205-097-5; iodairal; renumbral; orthoiodin; iodohippuratesodium; hippodin; urocontrast

物化性质

• 沸点: 480.9ºC at 760mmHg
• 分子式: C₉H₇INNaO₃
• 分子量: 327.05100
• 闪点: 244.6ºC
• 精确质量: 326.93700
• PSA: 69.23000
• LogP: 0.16180
• 蒸汽压: 4.67E-10mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MR8162000 CHEMICAL NAME : Hippuric acid, o-iodo-, monosodium salt CAS REGISTRY NUMBER : 133-17-5 LAST UPDATED : 199309 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C9-H7-I-N-O3.Na MOLECULAR WEIGHT : 327.06 WISWESSER LINE NOTATION : OVIMVR BI &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,394,1956 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,721,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MECHAN Medicinal Chemistry, A Series of Reviews. (New York, NY) V.1-6, 1951-63. Discontinued. Volume(issue)/page/year: 6,290,1963