123-30-8

123-30-8结构式

常用中文名：对氨基苯酚
常用英文名：4-Aminophenol
CAS号：123-30-8
分子式：C₆H₇NO
分子量：109.126
相关类别：有机原料醇、酚、酚醇类化合物及衍生物酚及其卤化、磺化、硝化或亚硝化衍生物
发布时间：2018-02-05 08:00:00
更新时间：2025-08-21 22:00:56
用途一：用作分析试剂
用途二：用于生产硫化蓝FBG、弱酸性嫩黄5G等染料，制造扑热息痛、安妥明等药物，也用于制显影剂、抗氧剂等
用途三：该品为医药、染料等精细化学品的中间体。用于生产药物扑热息痛、偶氮染料、硫化染料、酸性染料、毛皮染料以及显影剂、抗氧剂和石油添加剂等。
用途四：检定金，测定铜、铁、镁、钒、亚硝酸盐和氰酸盐，抗氧剂。

中文名	复硝酚钠
英文名	4-aminophenol
中文别名	4-氨基苯酚对氨基酚对氨基苯酚对羟基苯胺 4-羟基苯胺
英文别名	4-NH2-Phenol AZOL 4-amino-phenol Energol Unal Freedol Kathol 4-AMINOPHENOL 0,97 \|p\|-Aminophenol 4-AMINO-1-HYDROXYBENZENE P-AMINOPHNOL EINECS 204-616-2 CITOL 4-Hydroxyaniline para-hydroxyaniline 4-AMINO PHENOL ursolp 4-Aminophenol Acetaminophen Impurity K para-amino phenol Kodelon 4-NITROBENZENAMINE 4-AMINOPHENOL (4-HYDROXYANILINE) PARACETAMOL,IMP. K p-Aminophenol 4-AMINOPHENOL FOR SYNTHESIS renalac p-hydroxyphenylamine MFCD00007869 1-amino-4-hydroxybenzene P-AMINO PHENOL Paracetamol Impurity K 4-AMINOPHENOL/4-HYDROXYANILINE Mesalazine Impurity 1

密度	1.2±0.1 g/cm3
沸点	282.0±23.0 °C at 760 mmHg
熔点	188 °C
分子式	C₆H₇NO
分子量	109.126
闪点	124.3±22.6 °C
精确质量	109.052765
PSA	46.25000
LogP	-0.29
外观性状	灰白色粒状的粉末
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.637
储存条件	1.采用铁桶、纸桶或纤维板桶内衬塑料袋包装，每桶净重35kg、40kg或50kg。贮存时要避光，防止受热、受潮。按有毒危险品规定贮运。 2.储存注意事项储存于阴凉、通风的库房。远离火种、热源。包装密封。应与氧化剂、酸类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。
稳定性	1.水中溶解度：13℃时0.39%、24℃时0.65%、30℃时0.80%、50℃时1.5%、80℃时4.7%、96℃时8.5%。甲乙酮中溶解度：58.5℃时9.3%。无水乙醇中溶解度：0℃时4.5%。溶于热水和乙醇，微溶于水和甲乙酮，不溶于苯、甲苯和氯仿。 2.稳定性稳定 3.禁配物酸类、酰基氯、酸酐、氯仿、强氧化剂 4.避免接触的条件受热 5.聚合危害不聚合
水溶解性	1.5 g/100 mL (20 ºC)
分子结构	1、摩尔折射率：32.37 2、摩尔体积（cm³/mol）：90.1 3、等张比容（90.2K）：248.1 4、表面张力（dyne/cm）：57.4 5、极化率（10^-24cm³）：12.83
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:2 3.氢键受体数量:2 4.可旋转化学键数量:0 5.互变异构体数量:4 6.拓扑分子极性表面积46.2 7.重原子数量:8 8.表面电荷:0 9.复杂度:66.9 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：白色至灰褐色结晶 2.熔点（℃）：186~189 3.沸点（℃）：150（0.4kPa） 4.饱和蒸气压（kPa）：0.4（150℃） 5.辛醇/水分配系数：0.04 6.溶解性：微溶于水、乙醇、乙醚。

国标编号:	61720
ＣＡＳ:	123-30-8
中文名称:	4-氨基苯酚
英文名称:	4-aminophenol；p-aminophenol
别名:	对氨基苯酚
分子式:	C₆H₇NO；HOC₆H₄NH₂
分子量:	109.12
熔点:	184℃/分解沸点：15
密度:
蒸汽压:
溶解性:	微深于水、醇、醚
稳定性:	稳定，不聚合
外观与性状:	白色至灰褐色结晶
危险标记:	15(有害品，远离食品)
用途:	用于制造染料、药物及塑料固化剂等

对环境的影响:
一、健康危害

侵入途径：吸入、食入。
健康危害：本品不易经皮肤吸收，属致敏物质，能引起支气管哮喘，接触过敏性皮炎。吸入过量的本品粉尘可引起高铁血红蛋白血症。

二、毒理学资料及环境行为

急性毒性：LD50375mg/kg (大鼠经口)；人吸入1mg/m3，最小中毒浓度(血液影响)；人经口50mg/kg，最小致死剂量。
致突然袭击变性：微生物致突变性：鼠伤寒沙门氏菌2umol/皿。体细胞突变：小鼠淋巴细胞4mg/L。精子形态学：小鼠腹腔500mg/kg，5天。
生殖毒性：大鼠最低中毒剂量(TDL0)：563mg/kg(孕1～22天)，死胎。

危险特性：遇明火、高热可燃。与强氧化剂可发生反应。受热分解放出有毒的氧化氮烟气。
燃烧(分解)产物：一氧化碳、二氧化碳、氧化氮。

3.现场应急监测方法:
　

4.实验室监测方法:
极谱法(空气，苏联)
环境和废水试样中痕量2-、3-和4-氨基苯酚的电子浮获检测-GC测定[刊，日]/Osaki Y.；Matsueda T.//分析化学.-1988,37(2)-253～258 《分析化学文摘》1992-1993

5.环境标准:
前苏联(1975)工作环境空气中最大允许浓度 1mg/m3
前苏联水体中有害物质最高允许浓度 0.05mg/L

6.应急处理处置方法:
一、泄漏应急处理

隔离泄漏污染区，限制出入，切断火源，建议应急处理人员戴呼吸器，穿消防防护服。小量泄漏：用清洁的铲子收集于干燥，清净，有盖的空器中。大量泄漏：收集回收或运至废物处理场所处置。

二、防护措施

呼吸系统防护：空气中粉尘浓度超标时，佩戴自吸过滤式防尘口罩。紧急事态抢救或撤离时，应该佩戴空气呼吸器。
眼睛防护：戴化学安全防护眼镜。
身体防护：穿防毒物渗透工作服。
手防护：戴橡胶手套。
其它：工作现场禁止吸烟、进食和饮水。工作毕，淋浴更衣。单独存放被毒物污染的衣服，洗后务用。保持良好的卫生习惯。

三、急救措施

皮肤接触：脱去被污染的衣着，用肥皂水和清水彻底冲洗皮肤。
眼睛接触：提起眼睑，用流动清水或生理盐水冲洗，就医。
吸入：迅速脱离现场至空气新鲜处，保持呼吸通畅。如呼吸困难，给输氧，如呼吸停止，立即进行人工呼吸，就医。
食入：饮足量温水，催吐，就医。

灭火方法：雾状水、泡沫、二氧化碳、干粉、砂土。

毒理学数据:

1.急性毒性

LD50：375mg/kg（大鼠经口）；420mg/kg（小鼠经口）；10000mg/kg（兔经口）；＞10g/kg（兔经皮）。

LC50：＞5mg/m³（大鼠吸入，1h）

2.刺激性

家兔经皮：12500μg（24h），轻度刺激。

家兔经眼：100mg，轻度刺激。

3.致突变性微生物致突变性：鼠伤寒沙门菌2μmol/皿。体细胞突变：小鼠淋巴细胞4mg/L。精子形态学：小鼠腹腔500mg/kg（5d）。DNA损伤和抑制：人淋巴细胞250μmol/L。

4.致畸形仓鼠孕后8d静脉内给予最低中毒剂量（TDLo）100mg/kg，致中枢神经系统、眼、耳、肌肉骨骼系统发育畸形。

5.其他大鼠最低中毒剂量（TDLo）：563mg/kg（孕1~22d），死胎。

生态学数据:

1.生态毒性

LC50：24mg/L（96h）（黑头呆鱼）；2mg/L（48h）（金鱼）

EC50：0.032mg/L（水蚤）

2.生物降解性当4-氨基苯酚的COD值在200mg/L时，使用经过驯化的活性污泥，且污泥浓度达到100mg/L，在5d后（有氧），COD去除率为87%。

3.非生物降解性空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期5h（理论）。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ5075000

CHEMICAL NAME :: Phenol, p-amino-

CAS REGISTRY NUMBER :: 123-30-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 53

MOLECULAR FORMULA :: C6-H7-N-O

MOLECULAR WEIGHT :: 109.14

WISWESSER LINE NOTATION :: ZR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 mg/kg/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 465 mg/kg

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 675 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis Blood - methemoglobinemia-carboxyhemoglobin Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1530 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 563 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 56200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1326 mg/kg/4W-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 667 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 38850 mg/kg

SEX/DURATION :: female 13 week(s) pre-mating female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 11100 mg/kg

SEX/DURATION :: female 13 week(s) pre-mating female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 563 mg/kg

SEX/DURATION :: female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 150 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - body wall

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 100 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 150 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - body wall

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 10 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 26,163,1995 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1481 No. of Facilities: 5320 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 49882 (estimated) No. of Female Employees: 37110 (estimated)

符号	GHS07, GHS08, GHS09
信号词	Warning
危害声明	H302 + H332-H341-H410
警示性声明	P261-P280-P301 + P312 + P330
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲)	Xn:Harmful
风险声明 (欧洲)	R20/22;R50/53;R68
安全声明 (欧洲)	S28-S36/37-S60-S61-S28A
危险品运输编码	UN 2512 6.1/PG 3
WGK德国	3
RTECS号	SJ5075000
包装等级	III
危险类别	6.1
海关编码	2922299090

上游产品 9
100-02-7 98-95-3 36309-42-9 89415-43-0
24541-43-3 1145-76-2 84253-23-6 54840-15-2
104-94-9
下游产品 10
105745-91-3 57478-19-0 35607-02-4 55996-28-6
110360-78-6 56705-83-0 32604-29-8 3139-28-4
536-80-1 50700-49-7

1. 铁粉还原法由对硝基酚还原而得。原料消耗定额：硝基苯酚（工业品）1388kg/t、铁粉1778kg/t、30%盐酸200kg/t。

2. 苯酚亚硝化法由苯酚经亚硝化、还原、酸析而得。

3. 偶合还原法以苯胺为原料，经重氮化、偶合、铁粉还原而得。

4. 硝基苯催化氢化法多以铂，钯或二者作催化剂，在10-20%硫酸水溶液中氢化还原为苯基羟胺，随即转位对氨基酚，收率70-80%。在反应系统中加入表面活性剂等对提高产率有一定效果。5.硝基苯电解还原法日本三井东压精细化学品公司采用在硫酸溶液中电解还原硝基苯，经苯基羟胺转位成对氨基酚，1977年6月该公司在大牟田工厂内建成一套1000吨/年装置。

海关编码	2922299090
中文概述	2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

25963-47-7	123-30-8
1017030-81-7	160446-03-7
1017031-24-1	1016864-49-5
1824283-62-6	869294-02-0
1016788-47-8	69853-43-6
147104-12-9	1261551-74-9

123-30-8

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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