862189-96-6

• 常用中文名：Mirodenafil dihydrochloride
• 常用英文名：Mirodenafil (dihydrochloride)
• CAS号：862189-96-6
• 分子式：C₂₆H₃₉Cl₂N₅O₅S
• 分子量：604.58900
• 相关类别： 信号通路 代谢酶/蛋白酶 磷酸二酯酶(PDE)
• 发布时间：2016-04-26 22:18:08
• 更新时间：2024-01-09 19:53:41
• Mirodenafil(SK3530)双盐酸盐是磷酸二酯酶5（PDE-5）抑制剂，可作用于勃起功能紊乱。

名称

• 中文名: Mirodenafil dihydrochloride
• 英文名: 5-Ethyl-2-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl}-2-propo xyphenyl)-7-propyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one d ihydrochloride
• 英文别名: Mirodenafil (dihydrochloride)

物化性质

• 分子式: C₂₆H₃₉Cl₂N₅O₅S
• 分子量: 604.58900
• 精确质量: 603.20500
• PSA: 129.40000
• LogP: 5.42430
• 储存条件: 2-8℃

生物活性

• 描述: Mirodenafil(SK3530)双盐酸盐是磷酸二酯酶5(PDE-5)抑制剂,可作用于勃起功能紊乱。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 其他
• 参考文献:

  [1]. Paick, J.S., et al., Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction. J Sex Med, 2008. 5(11): p. 2672-80.

  [2]. Kim, B.H., et al., Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: a single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea. Clin Ther, 2009. 31(6): p. 1234-43.

  [3]. Shin, K.H., et al., The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study. Clin Ther, 2009. 31(12): p. 3009-20.