223251-25-0

• 常用中文名：1-(2-(4-(氯甲基)苯氧基)乙基)氮杂环庚烷盐酸盐
• 常用英文名：1-[2-[4-(chloromethyl)phenoxy]ethyl]azepane,hydrochloride
• CAS号：223251-25-0
• 分子式：C₁₅H₂₃Cl₂NO
• 分子量：304.255
• 发布时间：2018-12-21 12:17:13
• 更新时间：2024-01-02 14:09:22

名称

• 中文名: 1-(2-(4-(氯甲基)苯氧基)乙基)氮杂烷盐酸盐
• 英文名: 1-[2-[4-(chloromethyl)phenoxy]ethyl]azepane,hydrochloride
• 中文别名: 醋酸巴多昔芬中间体2
• 英文别名: (4-chloromethyl-phenoxy)-ethyl-hexamethyleneimine-1-yl hydrochloride; 4-(2-azepan-1-ylethoxy)benzyl chloride hydrochloride; 1-[2-(4-chloromethyl-phenoxy)-ethyl]-azepane hydrochloride; 1H-Azepine, 1-[2-[4-(chloromethyl)phenoxy]ethyl]hexahydro-, hydrochloride (1:1); 1-{2-[4-(Chloromethyl)phenoxy]ethyl}azepane hydrochloride (1:1)

物化性质

• 分子式: C₁₅H₂₃Cl₂NO
• 分子量: 304.255
• 精确质量: 303.115662
• PSA: 12.47000
• LogP: 4.42010
• 外观性状: 固体
• 储存条件: 2-8℃，惰性气体

安全

• 危害码 (欧洲): Xi

合成路线

223251-16-9 ~61% 223251-25-0

文献：DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna Patent: WO2011/22596 A2, 2011 ; Location in patent: Page/Page column 4; 24 ;

328933-65-9 ~% 223251-25-0

文献：Wyeth Patent: EP1212335 B1, 2006 ; Location in patent: Page/Page column 25 ; EP 1212335 B1

623-05-2 ~% 223251-25-0

文献：Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5795 - 5798 Angew. Chem., 2013 , p. 5999

26487-67-2 ~% 223251-25-0

文献：DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna Patent: WO2011/22596 A2, 2011 ;

2205-31-4 ~% 223251-25-0

文献：Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5795 - 5798 Angew. Chem., 2013 , p. 5999

上下游产品

上游产品  5
223251-16-9 328933-65-9 623-05-2 26487-67-2
2205-31-4
下游产品  2
198481-32-2 198480-21-6