662116-67-8

• 常用中文名：2-氨基-4,5-二氯-3-硝基吡啶
• 常用英文名：4,5-Dichloro-3-nitro-2-pyridinamine
• CAS号：662116-67-8
• 分子式：C₅H₃Cl₂N₃O₂
• 分子量：208.002
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 硝基吡啶
• 发布时间：2018-12-31 12:44:54
• 更新时间：2024-01-09 19:08:09

名称

• 中文名: 2-氨基-4,5-二氯-3-硝基吡啶
• 英文名: 4,5-dichloro-3-nitropyridin-2-amine
• 英文别名: 2-Pyridinamine, 4,5-dichloro-3-nitro-; 2-amino-3-nitro-4,5-dichloropyridine; RW3676; 4,5-dichloro-3-nitropyridin-2-ylamine; 4,5-Dichloro-3-nitro-2-pyridinamine; 2-Amino-4,5-dichloro-3-nitropyridine

物化性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 337.2±37.0 °C at 760 mmHg
• 分子式: C₅H₃Cl₂N₃O₂
• 分子量: 208.002
• 闪点: 157.7±26.5 °C
• 精确质量: 206.960236
• PSA: 85.46000
• LogP: 3.18
• 外观性状: 浅黄色到黄棕色液体
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.667
• 储存条件: 2-8°C， 惰性气氛

安全

• 危害码 (欧洲): Xn
• 海关编码: 2933399090

合成路线

6980-08-1 ~84% 662116-67-8

文献：CANCER RESEARCH TECHNOLOGY LIMITED; BLAGG, Julian; BAVETSIAS, Vassilios; MOORE, Andrew S.; LINARDOPOULOS, Spyridon Patent: WO2013/190319 A1, 2013 ; Location in patent: Paragraph 00118 ;

188577-71-1 ~54% 662116-67-8

文献：ASTRAZENECA AB Patent: WO2004/16611 A1, 2004 ; Location in patent: Page 97-98 ; WO 2004/016611 A1

188577-68-6 ~26% 662116-67-8

文献：Bavetsias, Vassilios; Large, Jonathan M.; Sun, Chongbo; Bouloc, Nathalie; Kosmopoulou, Magda; Matteucci, Mizio; Wilsher, Nicola E.; Martins, Vanessa; Reynisson, Johannes; Atrash, Butrus; Faisal, Amir; Urban, Frederique; Valenti, Melanie; De Haven Brandon, Alexis; Box, Gary; Raynaud, Florence I.; Workman, Paul; Eccles, Suzanne A.; Bayliss, Richard; Blagg, Julian; Linardopoulos, Spiros; McDonald, Edward Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5213 - 5228

19798-80-2 ~% 662116-67-8

文献：Bavetsias, Vassilios; Crumpler, Simon; Sun, Chongbo; Avery, Sian; Atrash, Butrus; Faisal, Amir; Moore, Andrew S.; Brown, Nathan; Sheldrake, Peter W.; Bush, Katherine; Henley, Alan; Box, Gary; Valenti, Melanie; De Haven Brandon, Alexis; Raynaud, Florence I.; Workman, Paul; Eccles, Suzanne A.; Linardopoulos, Spiros; Blagg, Julian; Kosmopoulou, Magda; Bayliss, Richard Journal of Medicinal Chemistry, 2012 , vol. 55, # 20 p. 8721 - 8734,14 Title/Abstract Full Text Show Details Bavetsias, Vassilios; Crumpler, Simon; Sun, Chongbo; Avery, Sian; Atrash, Butrus; Faisal, Amir; Moore, Andrew S.; Kosmopoulou, Magda; Brown, Nathan; Sheldrake, Peter W.; Bush, Katherine; Henley, Alan; Box, Gary; Valenti, Melanie; De Haven Brandon, Alexis; Raynaud, Florence I.; Workman, Paul; Eccles, Suzanne A.; Bayliss, Richard; Linardopoulos, Spiros; Blagg, Julian Journal of Medicinal Chemistry, 2012 , vol. 55, # 20 p. 8721 - 8734

188577-70-0 ~% 662116-67-8

文献：HANMI PHARM. CO., LTD.; LEE, Kyung Ik; SIM, Jae Yi; KIM, Ho Seok; HA, Tae Hee; SUH, Kwee Hyun Patent: WO2013/100631 A1, 2013 ;

上下游产品

上游产品  5
6980-08-1 188577-71-1 188577-68-6 19798-80-2
188577-70-0
下游产品  1
662116-66-7

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%