116-44-9

• 常用中文名：Benzenesulfonamide,4-amino-N-2-pyrazinyl-
• 常用英文名：Benzenesulfonamide,4-amino-N-2-pyrazinyl-
• CAS号：116-44-9
• 分子式：C₁₀H₁₀N₄O₂S
• 分子量：250.27700
• 发布时间：2016-01-05 03:56:56
• 更新时间：2025-09-10 18:57:46

名称

• 英文名: 4-amino-N-pyrazin-2-ylbenzenesulfonamide
• 英文别名: SULFAPYRAZINE; 4-amino-N-pyrazin-2-yl-benzenesulfonamide; 2-Sulfanilamidopyrazine; sulfanilic acid pyrazin-2-ylamide; N(sup 1)-2-Pyrazinylsulfonilamide; Sulfanilamide,N1-(pyrazinyl); Benzenesulfonamide,4-amino-N-pyrazinyl; Sulfanilsaeure-pyrazin-2-ylamid; Pyrazine,sulfanilamido; N1-2-Pyrazinylsulfanilamide; 4-amino-N-2-pyrazinylbenzenesulfonamide; 4-amino-N-pyrazinyl-benzenesulfonamide

物化性质

• 密度: 1.496g/cm3
• 沸点: 485.5ºC at 760mmHg
• 分子式: C₁₀H₁₀N₄O₂S
• 分子量: 250.27700
• 闪点: 247.4ºC
• 精确质量: 250.05200
• PSA: 106.35000
• LogP: 2.59460
• 蒸汽压: 1.41E-09mmHg at 25°C
• 折射率: 1.679

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DA9550000 CHEMICAL NAME : Benzenesulfonamide, 4-amino-N-pyrazinyl- CAS REGISTRY NUMBER : 116-44-9 BEILSTEIN REFERENCE NO. : 0235481 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C10-H10-N4-O2-S MOLECULAR WEIGHT : 250.30 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 45600 mg/kg/22W-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes Endocrine - thyroid weight (goiter) Related to Chronic Data - death REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 45 gm/kg/90D-C TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943

安全

• 海关编码: 2935009090

合成路线

5433-91-0 ~% 116-44-9

文献：Journal of the American Chemical Society, , vol. 63, p. 3153 US2420703 , ;

14508-49-7 63-74-1 ~% 116-44-9

文献：US2444012 , ;

121-60-8 ~% 116-44-9

文献：Journal of the American Chemical Society, , vol. 63, p. 3153 US2420703 , ;

上下游产品

上游产品  4
5433-91-0 121-60-8 14508-49-7 63-74-1
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海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%