CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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UQ2010000
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CHEMICAL NAME :
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Pyrazinamine, N-nitroso-
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CAS REGISTRY NUMBER :
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103829-56-7
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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3
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MOLECULAR FORMULA :
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C4-H4-N4-O
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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176 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair
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REFERENCE :
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB88-239900
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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25 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Blood - leukopenia Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 29,511,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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150 mg/kg/5D-I
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TOXIC EFFECTS :
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Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death Related to Chronic Data - changes in testicular weight
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REFERENCE :
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB88-239900
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