CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GO7350000
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CHEMICAL NAME :
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o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-, dihydrochloride
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CAS REGISTRY NUMBER :
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10350-81-9
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LAST UPDATED :
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199709
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DATA ITEMS CITED :
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8
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MOLECULAR FORMULA :
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C20-H20-Cl-N3-O.2Cl-H
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MOLECULAR WEIGHT :
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426.80
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WISWESSER LINE NOTATION :
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T66 BNJ IG EMR DQ C1- AT5NTJ &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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410 mg/kg
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TOXIC EFFECTS :
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Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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34 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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580 mg/kg
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TOXIC EFFECTS :
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Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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35 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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30 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity)
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REFERENCE :
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AJTHAB American Journal of Tropical Medicine and Hygiene. (Allen Press, 1041 New Hampshire St., Lawrence, KS 66044) V.1- 1952- Volume(issue)/page/year: 6,987,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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36876 mg/kg/12W-C
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - dehydration Related to Chronic Data - death
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REFERENCE :
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ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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1320 mg/kg/2W-I
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting Related to Chronic Data - death
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REFERENCE :
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ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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120 mg/kg/16D-I
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity)
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REFERENCE :
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ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
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