Top Suppliers:I want be here

10350-81-9

10350-81-9 structure
10350-81-9 structure

Name Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:2)
Synonyms 4-(7-Chlor-chinolyl-(4)-amino)-2-pyrrolidinomethyl-phenol-dihydrochlorid
1-Naphthol,4-((7-chloro-4-quinolyl)amino)-2-((diethylamino)methyl)-5,6,7,8-tetrahydro
4-(7-chloro-quinolin-4-ylamino)-2-diethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-1-ol
1-Naphthalenol,4-((7-chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-5,6,7,8-tetrahydro
4-(7-Chlor-4-chinolylamino)-2-diethylaminomethyl-5,6,7,8-tetrahydro-I-naphthol
Density 1.351g/cm3
Boiling Point 498.1ºC at 760mmHg
Molecular Formula C20H21Cl2N3O
Molecular Weight 390.30600
Flash Point 255.1ºC
Exact Mass 389.10600
PSA 48.39000
LogP 5.74610

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GO7350000
CHEMICAL NAME :
o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-, dihydrochloride
CAS REGISTRY NUMBER :
10350-81-9
LAST UPDATED :
199709
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C20-H20-Cl-N3-O.2Cl-H
MOLECULAR WEIGHT :
426.80
WISWESSER LINE NOTATION :
T66 BNJ IG EMR DQ C1- AT5NTJ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
410 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
34 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
580 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
AJTHAB American Journal of Tropical Medicine and Hygiene. (Allen Press, 1041 New Hampshire St., Lawrence, KS 66044) V.1- 1952- Volume(issue)/page/year: 6,987,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
36876 mg/kg/12W-C
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - dehydration Related to Chronic Data - death
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1320 mg/kg/2W-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting Related to Chronic Data - death
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
120 mg/kg/16D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958