33178-86-8

• 常用中文名：烯丙尼定
• 常用英文名：Alinidine
• CAS号：33178-86-8
• 分子式：C₁₂H₁₃Cl₂N₃
• 分子量：270.15800
• 发布时间：2018-09-11 11:02:26
• 更新时间：2024-01-02 17:45:10
• Alinidine is an anti-arrythmic that reduces heart-rate without blockade of beta-adrenoceptors.

名称

• 中文名: 烯丙尼定
• 英文名: N-(2,6-dichlorophenyl)-N-prop-2-enyl-4,5-dihydro-1H-imidazol-2-amine
• 中文别名: 烯苯胺咪
• 英文别名: Alinidina [INN-Spanish]; 2-[N-(2,6-dichloro-phenyl)-N-allyl-amino]-2-imidazoline; ST-567; Alinidin; 2-IMIDAZOLINE,2-(N-ALLYL-2,6-DICHLOROANILINO); Alinidinum [INN-Latin]; 2-(N-Allyl-N-(2,6-dichlorophenyl)amino)-2-imidazoline; Alinidine; allyl-(2,6-dichloro-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine

物化性质

• 密度: 1.3g/cm3
• 沸点: 360.2ºC at 760mmHg
• 分子式: C₁₂H₁₃Cl₂N₃
• 分子量: 270.15800
• 闪点: 171.7ºC
• 精确质量: 269.04900
• PSA: 27.63000
• LogP: 2.70940
• 折射率: 1.611
• 储存条件: 2-8°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ1552500 CHEMICAL NAME : 2-Imidazoline, 2-(N-allyl-2,6-dichloroanilino)- CAS REGISTRY NUMBER : 33178-86-8 BEILSTEIN REFERENCE NO. : 0961200 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C12-H13-Cl2-N3 MOLECULAR WEIGHT : 270.18 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 2,193,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 2,193,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 242 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 2,193,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 2,193,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 2,193,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 2,193,1984 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 27500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 2,193,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 148 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 2,193,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 17400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 2,193,1984

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22-36/37/38

合成路线

106-95-6 4205-90-7 ~55% 33178-86-8

文献：Journal of Medicinal Chemistry, , vol. 23, # 11 p. 1217 - 1222

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