365-12-8

• 常用中文名：2'-氟-[1,1'-联苯]-4-羧酸
• 常用英文名：2'-Fluoro-[1,1'-biphenyl]-4-carboxylic acid
• CAS号：365-12-8
• 分子式：C₁₃H₉FO₂
• 分子量：216.20800
• 发布时间：2018-02-20 08:00:00
• 更新时间：2024-01-10 18:52:00

名称

• 中文名: 2-氟联苯-4-羧酸
• 英文名: 2'-Fluorobiphenyl-4-carboxylic acid
• 中文别名: 2'-氟二苯-4-甲酸
• 英文别名: 4-(2-fluorophenyl)benzoic acid; 2'-Fluoro-[1,1'-biphenyl]-4-carboxylic acid; MFCD00278732

物化性质

• 密度: 1.261 g/cm3
• 沸点: 363.9ºC at 760 mmHg
• 熔点: 234ºC
• 分子式: C₁₃H₉FO₂
• 分子量: 216.20800
• 闪点: 173.9ºC
• 精确质量: 216.05900
• PSA: 37.30000
• LogP: 3.19090
• 储存条件: 室温，干燥，密封

MSDS

Name: 2 -Fluoro[1 1 -biphenyl]-4-carboxylic acid 97% Material Safety Data Sheet Synonym: CAS: 365-12-8 Section 1 - Chemical Product MSDS Name:2 -Fluoro[1 1 -biphenyl]-4-carboxylic acid 97% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 365-12-8 2'-Fluoro[1,1'-biphenyl]-4-carboxylic 97% unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 365-12-8: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: Not available. Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 234 - 236 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C13H9FO2 Molecular Weight: 216.21 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, fluorine, hydrogen fluoride gas. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 365-12-8 unlisted. LD50/LC50: Not available. Carcinogenicity: 2'-Fluoro[1,1'-biphenyl]-4-carboxylic acid - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 365-12-8: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 365-12-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 365-12-8 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36/37/39
• 海关编码: 2916399090

合成路线

72093-41-5 ~99% 365-12-8

文献：Pfizer Inc. Patent: US4623650 A1, 1986 ;

391-08-2 ~% 365-12-8

文献：Journal of the American Chemical Society, , vol. 68, p. 1159

773139-82-5 ~% 365-12-8

文献：Bright, Tara V.; Dalton, Fay; Elder, Victoria L.; Murphy, Cormac D.; O'Connor, Neil K.; Sandford, Graham Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1135 - 1142

80254-85-9 ~% 365-12-8

文献：Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 1 p. 35 - 38

5798-75-4 1993-03-9 ~% 365-12-8

文献：Organic and Biomolecular Chemistry, , vol. 11, # 7 p. 1135 - 1142

345-55-1 ~% 365-12-8

文献：Journal of the Chemical Society [Section] C: Organic, , p. 840 - 845

321-60-8 ~% 365-12-8

文献：Journal of the Chemical Society [Section] C: Organic, , p. 840 - 845

上下游产品

上游产品  8
72093-41-5 391-08-2 773139-82-5 80254-85-9
5798-75-4 1993-03-9 345-55-1 321-60-8
下游产品  2
57592-42-4 773872-57-4

海关

海关编码	2916399090
中文概述	2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%