356058-42-9

• 常用中文名：2-(2-((4-氟苄基)硫基)-4-氧代-4,5,6,7-四氢-1H-环戊二烯并[d]嘧啶-1-基)乙酸
• 常用英文名：1H-Cyclopentapyrimidine-1-acetic acid, 2-[[(4-fluorophenyl)Methyl]thio]-4,5,6,7-tetrahydro-4-oxo-
• CAS号：356058-42-9
• 分子式：C₁₆H₁₅FN₂O₃S
• 分子量：334.365
• 发布时间：2016-08-25 08:10:27
• 更新时间：2024-01-31 21:33:04

名称

• 中文名: 2-(2-((4-氟苄基)硫基)-4-氧代-4,5,6,7-四氢-1H-环戊二烯并[d]嘧啶-1-基)乙酸
• 英文名: 2-[2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-1-yl]acetic acid
• 英文别名: (2-{[(4-fluorophenyl)methyl]thio}-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid; {2-[(4-Fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}acetic acid; 1H-Cyclopenta[d]pyrimidine-1-acetic acid, 2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-; QC-5139; 2-(2-((4-fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid; 2-[2-(4-fluorobenzylthio)-5,6-trimethylene-4-oxo-4H-pyrimidin-1-yl]acetic acid

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 542.3±60.0 °C at 760 mmHg
• 分子式: C₁₆H₁₅FN₂O₃S
• 分子量: 334.365
• 闪点: 281.8±32.9 °C
• 精确质量: 334.078735
• PSA: 97.49000
• LogP: 2.71
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.672
• 储存条件: -20°C，避光干燥

合成路线

1349902-20-0 352-11-4 ~94% 356058-42-9

文献：GLAXO GROUP LIMITED; CARDWELL, Kevin, Stuart; CRAWFORD, Claire, Frances; DAVIES, Suzanne, Helen; WADE, Charles, Edward Patent: WO2011/146494 A1, 2011 ; Location in patent: Page/Page column 11 ;

451487-18-6 ~% 356058-42-9

文献：Shanghai Institute of Materia Medica, Chinese Academy of Sciences; SHEN, Jianhua; WANG, Yiping; WANG, Kai Patent: EP2725024 A1, 2014 ;

611-10-9 ~% 356058-42-9

文献：Blackie, Josie A.; Bloomer, Jackie C.; Brown, Murray J. B.; Cheng, Hung-Yuan; Hammond, Beverley; Hickey, Deirdre M. B.; Ife, Robert J.; Leach, Colin A.; Lewis, V. Ann; Macphee, Colin H.; Milliner, Kevin J.; Moores, Kitty E.; Pinto, Ivan L.; Smith, Stephen A.; Stansfield, Ian G.; Stanway, Steven J.; Taylor, Maxine A.; Theobald, Colin J. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1067 - 1070

35563-27-0 ~% 356058-42-9

文献：Shanghai Institute of Materia Medica, Chinese Academy of Sciences; SHEN, Jianhua; WANG, Yiping; WANG, Kai Patent: EP2725024 A1, 2014 ;

10472-24-9 ~% 356058-42-9

文献：Nagano, Joseph M.G.; Hsu, Ku-Lung; Whitby, Landon R.; Niphakis, Micah J.; Speers, Anna E.; Brown, Steven J.; Spicer, Timothy; Fernandez-Vega, Virneliz; Ferguson, Jill; Hodder, Peter; Srinivasan, Prabhavathi; Gonzalez, Tara D.; Rosen, Hugh; Bahnson, Brian J.; Cravatt, Benjamin F. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 839 - 843

1349902-19-7 ~% 356058-42-9

文献：Nagano, Joseph M.G.; Hsu, Ku-Lung; Whitby, Landon R.; Niphakis, Micah J.; Speers, Anna E.; Brown, Steven J.; Spicer, Timothy; Fernandez-Vega, Virneliz; Ferguson, Jill; Hodder, Peter; Srinivasan, Prabhavathi; Gonzalez, Tara D.; Rosen, Hugh; Bahnson, Brian J.; Cravatt, Benjamin F. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 839 - 843

459-46-1 ~% 356058-42-9

文献：Shanghai Institute of Materia Medica, Chinese Academy of Sciences; SHEN, Jianhua; WANG, Yiping; WANG, Kai Patent: EP2725024 A1, 2014 ;

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