| 中文名 | 盐酸曲马多 |
|---|---|
| 英文名 | (1R,2S)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol,hydrochloride |
| 英文别名 |
trans-Tramadol HCl
Crispin trans-Tramadol hydrochloride Cyclohexanol,2-((dimethylamino)methyl)-1-(m-methoxyphenyl)-,hydrochloride,(E) cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride Cyclohexanol,2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-,hydrochloride,trans Cyclohexanol,2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-,hydrochloride,(1R,2S)-rel Tramadol Hydrochloride |
| 沸点 | 388.1ºC at 760 mmHg |
|---|---|
| 分子式 | C16H26ClNO2 |
| 分子量 | 299.83600 |
| 闪点 | 188.5ºC |
| 精确质量 | 299.16500 |
| PSA | 32.70000 |
| LogP | 3.43660 |
| 储存条件 | 库房低温,通风,干燥,与食品原料分开存放 |
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Section 1. Chemical Product and Company Identification Tramadol HydrochlorideCatalog T1286, T1620 Common Name/ Number(s). Trade Name 73806-49-2
CAS# Manufacturer Commercial Name(s) Tramadol Hydrochloride Section 3. Hazards Identification Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of Potential Acute Health inhalation. Effects CARCINOGENIC EFFECTS: Not available. Potential Chronic Health MUTAGENIC EFFECTS: Not available. Effects TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to kidneys, liver, central nervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage. Section 4. First Aid Measures Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least Eye Contact 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Skin Contact Cold water may be used. Not available. Serious Skin Contact If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get Inhalation medical attention. Not available. Serious Inhalation Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an Ingestion unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Not available. Serious Ingestion Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Not available. Flash Points Not available. Flammable Limits These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Products of Combustion Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks. Various Substances Slightly explosive in presence of open flames and sparks. Explosion Hazards in Non-explosive in presence of shocks. Presence of Various Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media LARGE FIRE: Use water spray, fog or foam. Do not use water jet. and Instructions As with most organic solids, fire is possible at elevated temperatures Special Remarks on Fire Hazards Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust Special Remarks on explosion hazard. Explosion Hazards Tramadol Hydrochloride Section 6. Accidental Release Measures Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading Small Spill water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on Large Spill the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. Wear suitable Precautions protective clothing. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents. Keep container tightly closed. Keep container in a cool, well-ventilated area. Storage Section 8. Exposure Controls/Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below Engineering Controls recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE of a Large Spill handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Solid. (Crystalline powder.)Odorless. Physical state andO dor appearance Bitter. Taste 299.88 g/mole Molecular Weight White. Off-white. Color 5-6 pH (1% soln/water) Not available. Boiling Point 178°C (352.4°F) - 181 C Melting Point Not available. Critical Temperature Not available. Specific Gravity Not applicable. Vapor Pressure Not available. Vapor Density Not available. Volatility Not available. Odor Threshold Not available. Water/Oil Dist. Coeff. Not available. Ionicity (in Water) See solubility in water. Dispersion Properties Soluble in cold water. Solubility Soluble in ethanol Tramadol Hydrochloride Section 10. Stability and Reactivity Data The product is stable. Stability Not available. Instability Temperature Conditions of Instability Excess heat, dust generation, incompatible materials, light. Incompatibility with various Reactive with oxidizing agents. substances Not available. Corrosivity Not available. Special Remarks on Reactivity Not available. Special Remarks on Corrosivity Will not occur. Polymerization Section 11. Toxicological Information Inhalation. Ingestion. Routes of Entry Acute oral toxicity (LD50): 228 mg/kg [Rat]. Toxicity to Animals Chronic Effects on Humans May cause damage to the following organs: kidneys, liver, central nervous system (CNS). Other Toxic Effects onHazardous in case of ingestion. HumansSlightly hazardous in case of skin contact (irritant), of inhalation. Lethal Dose/Conc 50% Kill: Special Remarks on LD50[Rabbit] - Route: Oral; Dose: 500 mg/kg Toxicity to Animals Excreted in maternal milk in human. Special Remarks on Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: Causes mild eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: Harmful if swallowed. May cause clammy skin, sweating, drry mouth, stomach upset, nausea, vomiting, hypermotility and diarrhea, or constipation. May affect behavior/central nervous system (ataxia, anxiety, weakness, irritability, mental confusion, disorientation, headache, analgesia, dizziness, drowsiness, lightheadedness, seizures/convulsions, deep sleep, loss of conciouosness), respiration (dyspnea). It may also cause chest pain, rapid or slow heart rate, allergic reaction (rash, itching, swelling, breathing trouble). Chronic Potential Health Effects: Ingestion: Repeated or prolonged ingestion may affect liver, urinary system (bladder, kidneys), metabolism (weight loss), Endocrine system (hyperglycemia), behavior/central nervous system(symptoms similar to that of acute ingestion). Section 12. Ecological Information Ecotoxicity in water (LC50): 6.2 mg/l 96 hours [Fish (Goldfish)]. Ecotoxicity Not available. BOD5 and COD Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The products of degradation are less toxic than the product itself. Toxicity of the Products of Biodegradation Not available. Special Remarks on the Products of Biodegradation Tramadol Hydrochloride Section 13. Disposal Considerations Waste must be disposed of in accordance with federal, state and local environmental control Waste Disposal regulations. Section 14. Transport Information CLASS 6.1: Poisonous material. DO T Cl assi fi cati on UNNA: 2811 : Toxic solids, organic, n.o.s (Tramadol Hydrochloride) PG: III Identification Not available. Special Provisions for Transport DO T (Pi ctograms) Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations California prop. 65: This product contains the following ingredients for which the State of California has found to California cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances. Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List (NDSL). China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Not listed on AICS. WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). Other Classifications R22- Harmful if swallowed.S46- If swallowed, seek medical advice DSCL (EEC) immediately and show this container or label. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) Tramadol Hydrochloride TDG(Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. SECTION 16 - ADDITIONAL INFORMATION N/A |
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CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| 危险品运输编码 | UN 2811 6.1 / PGIII |
|---|---|
| 海关编码 | 2906199090 |
| 海关编码 | 2906199090 |
|---|---|
| 中文概述 | 2906199090. 其他环烷醇，环烯醇及环萜烯醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0% |
| 申报要素 | 品名, 成分含量, 用途 |
| Summary | 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |