76849-19-9

• 常用中文名：N10)-PROPARGYL-5,8-DIDEAZAFOLIC ACID
• 常用英文名：N10)-PROPARGYL-5,8-DIDEAZAFOLIC ACID
• CAS号：76849-19-9
• 分子式：C₂₄H₂₃N₅O₆
• 分子量：477.46900
• 发布时间：2016-07-19 11:31:36
• 更新时间：2025-09-18 19:29:59

名称

• 英文名: 2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid
• 英文别名: N10-2-propargyl-5,8-dideazafolic acid; 5,8-dideaza-10-propargylfolate; 10-propargyl-5,8-dideazafolic acid; PDDF; CB-3717; N10-propargyl-5,8-dideazafolic acid

物化性质

• 密度: 1.41g/cm3
• 分子式: C₂₄H₂₃N₅O₆
• 分子量: 477.46900
• 精确质量: 477.16500
• PSA: 178.97000
• LogP: 2.57730
• 折射率: 1.666

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MA0600200 CHEMICAL NAME : L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)meth yl)-2-propynylamino) benzoyl)- CAS REGISTRY NUMBER : 76849-19-9 LAST UPDATED : 199803 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C24-H23-N5-O6 MOLECULAR WEIGHT : 477.52 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Fibroblast DOSE/DURATION : 200 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,2036,1988