40507-23-1

• 常用中文名：氟丙喹宗
• 常用英文名：Fluproquazone
• CAS号：40507-23-1
• 分子式：C₁₈H₁₇FN₂O
• 分子量：296.33900
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-09-29 17:37:33
• 更新时间：2024-01-07 17:56:48
• Fluproquazone 是一种镇痛剂,具有镇痛作用。

名称

• 中文名: 氟丙喹宗
• 英文名: 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
• 英文别名: fluproquazone; Fluproquazona [INN-Spanish]; 4-(4-fluoro-phenyl)-1-isopropyl-7-methyl-1H-quinazolin-2-one; 1-isopropyl-7-methyl-4-(p-fluorophenyl)-quinazolin-2(1H)-one; RF 46-790; 1-isopropyl-4-(4-fluorophenyl)-7-methyl-2(1H)-quinazolinone; 1-Isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone; SaH 46-790; 4-(p-Fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone; Tormosyl; Fluproquazonum [INN-Latin]; 2(1H)-Quinazolinone,4-(p-fluorophenyl)-1-isopropyl-7-methyl

物化性质

• 密度: 1.18g/cm3
• 沸点: 436.6ºC at 760 mmHg
• 分子式: C₁₈H₁₇FN₂O
• 分子量: 296.33900
• 闪点: 217.9ºC
• 精确质量: 296.13200
• PSA: 34.89000
• LogP: 4.09190
• 折射率: 1.596

生物活性

• 描述: Fluproquazone 是一种镇痛剂,具有镇痛作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Wheatley D. Analgesic properties of fluproquazone. Rheumatol Rehabil. 1982 May;21(2):98-100.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA3401000 CHEMICAL NAME : 2(1H)-Quinazolinone, 4-(p-fluorophenyl)-1-isopropyl-7-methyl- CAS REGISTRY NUMBER : 40507-23-1 BEILSTEIN REFERENCE NO. : 0891838 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C18-H17-F-N2-O MOLECULAR WEIGHT : 296.37 WISWESSER LINE NOTATION : T66 BNVNJ BY1&1 ER DF& I1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 650 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 34,879,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 742 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 180 mg/kg SEX/DURATION : female 14 day(s) pre-mating female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 500 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1450 mg/kg SEX/DURATION : female 15-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 435 mg/kg SEX/DURATION : female 15-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981

安全

• 海关编码: 2933990090

合成路线

7440-44-0 40507-24-2 ~% 40507-23-1

文献：Sandoz, Inc. Patent: US3937705 A1, 1976 ;

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%