75821-71-5

• 常用中文名：氯那唑酸钙
• 常用英文名：LONAZOLAC CALCIUM SALT
• CAS号：75821-71-5
• 分子式：C₃₄H₂₄CaCl₂N₄O₄
• 分子量：663.56300
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-05-28 08:00:00
• 更新时间：2024-01-15 02:54:52
• Lonazolac (hemicalcium) 是 Lonazolac 的钙盐形式。Lonazolac 是一种非甾体抗风湿剂,具有抗炎作用。

名称

• 中文名: 氯那唑酸钙
• 英文名: lonazolac calcium
• 英文别名: LONAZOLAC CALCIUM SALT; Arthro akut; Bis[1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-acetic acid]calcium salt; Argun l; Irritren; calcium bis[3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-acetate]; Lonazolac calcium; 1H-Pyrazole-4-acetic acid,3-(4-chlorophenyl)-1-phenyl-,calcium salt (2:1); Bis[3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid]calcium salt

物化性质

• 沸点: 525.1ºC at 760 mmHg
• 分子式: C₃₄H₂₄CaCl₂N₄O₄
• 分子量: 663.56300
• 闪点: 271.4ºC
• 精确质量: 662.08000
• PSA: 115.90000
• LogP: 4.97020

生物活性

• 描述: Lonazolac (hemicalcium) 是 Lonazolac 的钙盐形式。Lonazolac 是一种非甾体抗风湿剂,具有抗炎作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Trnavský K, et al. [Lonazolac - a new non-steroidal antirheumatic agent. Report of a double-blind crossover clinical study]. Fysiatr Revmatol Vestn. 1983;61(3):147-152.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ4915000 CAS REGISTRY NUMBER : 75821-71-5 LAST UPDATED : 199409 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C34-H24-Cl2-N4-O4.Ca MOLECULAR WEIGHT : 663.60 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 845 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,655,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 670 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,655,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 650 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,180,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 790 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,180,1982