303-33-3

• 常用中文名：天芥菜碱
• 常用英文名：Heliotrine
• CAS号：303-33-3
• 分子式：C₁₆H₂₇NO₅
• 分子量：313.389
• 相关类别： 信号通路 其他 其他
• 发布时间：2018-04-23 08:00:00
• 更新时间：2024-01-03 11:04:53
• Heliotrine 是一种单酯吡咯烷核生物碱,用于获得肝炎和肝硬化的模型。

名称

• 中文名: 7S-天芥菜碱
• 英文名: heliotrine
• 中文别名: 天芥菜碱
• 英文别名: (2S,3R)-2-Hydroxy-2-isopropyl-3-methoxy-buttersaeure-((7aR)-7c-hydroxy-(7ar)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethylester); (2S)-2-Hydroxy-2-[(R)-1-methoxyethyl]-3-methylbutyric acid [(1S,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl; (2S,3R)-2-hydroxy-2-isopropyl-3-methoxy-butyric acid-((7aR)-7c-hydroxy-(7ar)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester); 7S-Heliotrine; [(1S,7aR)-1-Hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl]methyl (2S,3R)-2-hydroxy-2-isopropyl-3-methoxybutanoate; Butanoic acid, 2-hydroxy-3-methoxy-2-(1-methylethyl)-, [(1S,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl ester, (2S,3R)-; Heliotrine; (2S)-2-Hydroxy-2-[(R)-1-methoxyethyl]-3-methylbutyric acid [(1S,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl ester; Heliotrin; 9-Heliotrylheliotridine

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 450.7±45.0 °C at 760 mmHg
• 熔点: 125-126 °C
• 分子式: C₁₆H₂₇NO₅
• 分子量: 313.389
• 闪点: 226.4±28.7 °C
• 精确质量: 313.188934
• PSA: 79.23000
• LogP: 1.04
• 外观性状: 粉末
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.541
• 储存条件: 2-8°C， 密封， 干燥， 避光

生物活性

• 描述: Heliotrine 是一种单酯吡咯烷核生物碱,用于获得肝炎和肝硬化的模型。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. R Schoental, et al. Pancreatic Islet-Cell and Other Tumors in Rats Given Heliotrine, a Monoester Pyrrolizidine Alkaloid, and Nicotinamide. Cancer Res. 1975 Aug;35(8):2020-4.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MH6125000 CHEMICAL NAME : Heliotrine CAS REGISTRY NUMBER : 303-33-3 LAST UPDATED : 199803 DATA ITEMS CITED : 31 MOLECULAR FORMULA : C16-H27-N-O5 MOLECULAR WEIGHT : 313.44 WISWESSER LINE NOTATION : T55 AN CUTJ D1OVXQY1&1&Y1&O1 FQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 296 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Kidney, Ureter, Bladder - hematuria TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 274 mg/kg TOXIC EFFECTS : Liver - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 251 mg/kg TOXIC EFFECTS : Liver - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 260 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 mg/kg/9D-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Blood - macrocytosis Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 460 mg/kg/6D-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 50 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 100 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 150 mg/kg SEX/DURATION : female 16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 200 mg/kg SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - Central Nervous System TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : Dominant lethal test TYPE OF TEST : Mutation test systems - not otherwise specified TYPE OF TEST : Micronucleus test MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Mammal - species unspecified Leukocyte DOSE/DURATION : 50 umol/L REFERENCE : AJBSAM Australian Journal of Biological Sciences. (Commonwealth Scientific and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic. 3002, Australia) V.6- 1953- Volume(issue)/page/year: 21,469,1968 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

安全

• 安全声明 (欧洲): 22-36/37/39-45
• 危险品运输编码: UN 1544
• 包装等级: III
• 危险类别: 6.1(b)