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137-08-6生产厂家

137-08-6价格

137-08-6

137-08-6结构式
137-08-6结构式
  • 常用中文名:维生素B5
  • 常用英文名:Calcium pantothenate
  • CAS号:137-08-6
  • 分子式:C9H16NO5.1/2Ca
  • 分子量:238.27
  • 相关类别: 医药中间体 杂环化合物 噻吩类化合物
  • 发布时间:2018-02-06 08:00:00
  • 更新时间:2024-01-02 19:30:45
  • 用途一:作食品强化剂。可用于婴幼儿食品,使用量为15~28mg/kg;在饮液中为2~4mg/kg。
    用途二:生化研究;组织培养基的营养成分。临床用于治疗维生素B缺乏症,周围神经炎,手术后肠绞痛。
    用途三:本品为维生素类药物,是辅酶A的组成部分。在混旋泛酸钙中,只有右旋体具有维生素活性,参与蛋白质、脂肪、糖在体内的新陈代谢。用于维生素B缺乏症及周围神经炎,以及手术后的肠绞痛。与维生素C合用可治疗播散性红斑狼疮。人体缺乏泛酸钙具有如下症状:(1)生长停止,体重减少,突然死亡。(2)皮肤、毛发障碍。(3)神经系统障碍。(4)消化器官失常,肝功能障碍。(5)影响抗体形成。(6)副肾障碍。每天人体需要泛酸钙(以泛酸计)约5mg。泛酸钙作为营养增补剂,用于食品加工。除特殊营养食品外,使用量须在1%(以钙计)以下(日本)。奶粉强化时为10mg/100g。烧酒、威士忌酒中添加0.02%可增强风味。蜂蜜中添加0.02%可防止冬季结晶。能缓冲咖啡因及糖精等的苦味。
    用途四:生物合成辅酶A的前提物质,由于泛酸的易潮解等不稳定特性,故用钙盐作替代物。

化源商城直购

中文名 泛酸钙
英文名 D-(+)-Pantothenic acid calcium salt
中文别名 维生素B5
(R)-(+)-N-(2,4-二羟基-3,3-二甲基-1-氧代丁基)-β-丙氨酸钙盐
英文别名 VITAMIN B3/B5
panthoject
(R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine calcium salt
D-Pantothenic acid calcium salt
DL-Calcium
Calcium D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-b-alaninate
calcium Pantothenate
EINECS 205-278-9
D-calcium pantothenate
dl-calcium pantothenate
N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-b-alanine Calcium Salt
calpanate
Calpan
Pantholin
VITAMIN B5
β-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, calcium salt (2:1)
pancal
calcium d-pantothenate
MFCD00002766
Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate
Calcium bis(3-{[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino}propanoate)
D-Pantothenic acid (hemicalcium salt)
密度 1.266g/cm3
沸点 551.5ºC at 760 mmHg
熔点 190 °C
分子式 C9H16NO5.1/2Ca
分子量 238.27
闪点 145 °C
PSA 191.72000
外观性状 白色结晶粉末
折射率 27 ° (C=5, H2O)
储存条件

储存于阴凉干燥处。

稳定性

D-泛酸钙具有维生素的生理活性,L-泛酸钙则无生理活性。D-泛酸钙参与蛋白质、脂肪、糖在体内的新陈代谢。

计算化学

1、 疏水参数计算参考值(XlogP):

2、 氢键供体数量:6

3、 氢键受体数量:10

4、 可旋转化学键数量:10

5、 互变异构体数量:3

6、 拓扑分子极性表面积(TPSA):219

7、 重原子数量:31

8、 表面电荷:0

9、 复杂度:233

10、同位素原子数量:0

11、确定原子立构中心数量:2

12、不确定原子立构中心数量:0

13、确定化学键立构中心数量:0

14、不确定化学键立构中心数量:0

15、共价键单元数量:3

更多

1. 性状:白色针状结晶或粉末。稍有甜味,但转而微苦,具有中等吸湿性,对空气和光稳定。水解的程度取决于pH值,pH在5-7之间的水溶液最稳定,热压消毒时水溶液不稳定,因此,必须采用过滤灭菌的方法消毒。

2. 熔点(分解,℃):195-196

3. PH 每克本品溶于2.8毫升水,水溶液pH7.2-8.0。

4. 溶解性:溶于甘油,微溶于乙醇和丙酮。 具吸湿性,对空气和光稳定。
Name: D-(+)-Pantothenic Acid Calcium Salt Material Safety Data Sheet
Synonym: Dextrocalcium Pantothenate; Pantothenate Calciu
CAS: 137-08-6
Section 1 - Chemical Product MSDS Name:D-(+)-Pantothenic Acid Calcium Salt Material Safety Data Sheet
Synonym:Dextrocalcium Pantothenate; Pantothenate Calciu

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
137-08-6 DIHYDROXYDIMETHYLOXOBU 100.0 205-278-9
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Light sensitive.Air sensitive.Moisture sensitive.
Potential Health Effects
Eye:
Contact may cause transient eye irritation.
Skin:
May cause skin irritation. Low hazard for usual industrial handling.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling.
Inhalation:
May cause respiratory tract irritation. Low hazard for usual industrial handling.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Do NOT get water inside containers. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation. Do not get water inside containers.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Avoid contact with air and sunlight. Keep from contact with moist air and steam.
Storage:
Do not store in direct sunlight. Keep refrigerated. (Store below 4C/39F.) Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Store protected from light and air.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 137-08-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: none reported
pH: 7.2-8.0, 5% solution
Vapor Pressure: Negligible.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 195 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble in water.
Specific Gravity/Density: Not available.
Molecular Formula: (C9H16NO5)2Ca
Molecular Weight: 476.3114

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, incompatible materials, light, dust generation, exposure to air, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 137-08-6: RU4375000 LD50/LC50:
CAS# 137-08-6: Oral, mouse: LD50 = 10 gm/kg; Oral, rat: LD50 = >10 gm/kg.
Carcinogenicity:
DIHYDROXYDIMETHYLOXOBU - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 137-08-6: 0
Canada
CAS# 137-08-6 is listed on Canada's DSL List.
CAS# 137-08-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 137-08-6 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

急性毒性数据:

大鼠经口LD50:>10mg/kg

大鼠腹腔LD50:820mg/kg

大鼠皮肤LD50:3400mg/kg

大鼠静脉LD50:830mg/kg

小鼠经口LC50:10mg/kg

小鼠腹腔LC50:920mg/kg

小鼠皮肤LCLo:2700 mg/kg

小鼠静脉LC50:910mg/kg

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RU4375000
CAS REGISTRY NUMBER :
137-08-6
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C18-H32-N2-O10.Ca
MOLECULAR WEIGHT :
476.60
WISWESSER LINE NOTATION :
QV2MVYQX1&1&1Q &-CA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,599,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
820 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,599,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,599,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
920 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
910 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,311,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83849 No. of Facilities: 398 (estimated) No. of Industries: 7 No. of Occupations: 22 No. of Employees: 19095 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83849 No. of Facilities: 1870 (estimated) No. of Industries: 10 No. of Occupations: 35 No. of Employees: 29697 (estimated) No. of Female Employees: 7601 (estimated)

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲) Xn: Harmful;
风险声明 (欧洲) R20/21/22
安全声明 (欧洲) S24/25
危险品运输编码 NONH for all modes of transport
WGK德国 1
RTECS号 RU4375000
海关编码 2936240000
上游产品  0

下游产品  2

1、由异丁醛经甲醛羟甲基化、加成、水解、酸化、内酯化、酰化、加成而得。

2、由丙烯腈、氨、氢氧化钠、氧化钙反应生成的β-氨基丙酸钙与由异丁醛、甲醛、氰化钠反应生成的α-羟基-β,β-二甲基-γ-丁内酯制得DL-泛酸钙,再经拆分制得。

海关编码 2924199090
中文概述 2924199090. 其他无环酰胺(包括无环氨基甲酸酯)(包括其衍生物及盐). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 包装
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%