尼泊金甲酯

尼泊金甲酯用途

Methyl Paraben 是从云南铁杉 (Tsuga dumosa) 中分离出来对羟基苯甲酸的甲酯,是一种标准化的过敏原。Methyl Paraben 是一种稳定的、非挥发性的化合物,在食品、药品和化妆品中用作防腐剂。Methyl Paraben的生理作用是通过增加组胺释放、细胞调控免疫实现的。

尼泊金甲酯作用

【用途一】
用作食品、化妆品及医药防霉剂
【用途二】
用作防腐剂，也用于医药及有机合成
【用途三】
防腐剂；抗微生物剂。
【用途四】
在医药工业中用作药剂的防腐杀菌剂，也用于有机合成及食品、香料、胶片等的护腐添加剂。用类似的生产方法生产的同类产品对羟基苯甲酸乙酯（尼泊金乙）、对羟基苯甲酸丙酯（尼泊金丙），也都是消毒防腐药。该品对皮肤有刺激性。
【用途五】
在医药工业中用作药剂的防腐杀菌剂，也用于有机合成及食品；香料；胶片等的护腐添加剂。

尼泊金甲酯名称

[ CAS 号 ]:
99-76-3

[ 中文名 ]:
尼泊金甲酯

[ 英文名 ]:
Methyl 4-hydroxybenzoate

[中文别名 ]:

[英文别名 ]:

methyl p-hydroxybenzoate
4-Hydroxybenzoic acid, methyl ester
4-(Carbomethoxy)phenol
Mekkings M
Benzoic acid, 4-hydroxy-, methyl ester
Methylparaben
4-(Methoxycarbonyl)phenol
Methyl parahydroxybenzoate
Killitol
Methyl chemosept

尼泊金甲酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

天然产物 >> 酚类

[参考文献]

[1]. Soni MG, et al. Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem Toxicol. 2002 Oct;40(10):1335-73.

[相关活性小分子]

尼泊金甲酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
265.5±13.0 °C at 760 mmHg

[ 熔点 ]:
125-128 °C(lit.)

[ 分子式 ]:
C₈H₈O₃

[ 分子量 ]:
152.147

[ 闪点 ]:
116.4±12.6 °C

[ 精确质量 ]:
152.047348

[ PSA ]:
46.53000

[ LogP ]:
1.87

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.547

[ 储存条件 ]:
库房低温,通风,干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
可溶于：甲醇

[ 凝固点 ]:
131℃

尼泊金甲酯MSDS

详细MSDS(安全技术说明书)

尼泊金甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2450000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, methyl ester

CAS REGISTRY NUMBER :: 99-76-3

BEILSTEIN REFERENCE NO. :: 0509801

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QR DVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 500 mg/L

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (96),55,1978 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80461 No. of Facilities: 4469 (estimated) No. of Industries: 33 No. of Occupations: 50 No. of Employees: 57029 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80461 No. of Facilities: 15369 (estimated) No. of Industries: 94 No. of Occupations: 117 No. of Employees: 590361 (estimated) No. of Female Employees: 398916 (estimated)

尼泊金甲酯安全信息

[ 危害声明 ]:
H412

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi,Xn

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
UN 2769

[ WGK德国 ]:
1

[ RTECS号 ]:
DH2450000

[ 海关编码 ]:
2918290000

尼泊金甲酯合成路线

详细合成路线

尼泊金甲酯上下游产品

尼泊金甲酯上游产品

尼泊金甲酯下游产品

尼泊金甲酯制备

1.由对羟基苯甲酸与甲醇酯化而得。将对羟基苯甲酸加入过量的甲醇中溶解，搅拌下缓缓加入浓硫酸。加热回流10h后倒入水中析出结晶，经水洗、碳酸钠溶液洗、水洗，得粗品。用水或25%乙醇重结晶而得成品。收率为85%。原料消耗（kg/t）对羟基苯甲酸 1200甲醇 1000

尼泊金甲酯海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

尼泊金甲酯文献

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