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一硫化四甲基秋兰姆

一硫化四甲基秋兰姆用途

【用途一】
用于制造电缆、轮胎、胶管、胶带等艳色和透明制品
【用途二】
橡胶促进剂，主要用于制造电缆、轮胎、胶管、胶带、艳色制品和透明制品、鞋类、耐热制品等。

一硫化四甲基秋兰姆名称

[ CAS 号 ]:
97-74-5

[ 中文名 ]:
一硫化四甲基秋兰姆

[ 英文名 ]:
Tetramethylthiuram sulfide

[中文别名 ]:

[英文别名 ]:

Tetramethylthiuram sulfide
Trithiodicarbonic diamide, N,N,N',N'-tetramethyl-
Sulfide, bis[(dimethylamino)thioxomethyl]
EINECS 202-605-7
N,N,N',N'-Tetramethyldicarbonotrithioic diamide
Bis(dimethylthiocarbamyl) sulfide
MFCD00014870
Bis(dimethylthiocarbamyl) monosulfide
TMTM

一硫化四甲基秋兰姆生物活性

[ 描述 ]:

四甲基秋兰姆一硫化物(TMTM)是一种活性化合物。四甲基秋兰姆一硫化物(TMTM)可用于橡胶研究和各种生化研究[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Coleman, et al. Vibrational spectra of thiuram sulfides. Normal coordinate analysis of tetramethylthiuram mono-, di-, and tetrasulfides. Journal of Polymer Science, Polymer Physics Edition.Volume: 12.Issue: 5.Pages: 1001-13.Journal.1974.

[2]. Yingtao Sun, et al. Synergistic Effect of Copper Sulfate and Tetramethylthiuram Monosulfide Induced Metal-Coordination Cross-Linking in Nitrile–Butadiene Rubber. 25 April 2021.

一硫化四甲基秋兰姆物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
260.9±23.0 °C at 760 mmHg

[ 熔点 ]:
107-111 °C(lit.)

[ 分子式 ]:
C₆H₁₂N₂S₃

[ 分子量 ]:
208.368

[ 闪点 ]:
111.6±22.6 °C

[ 精确质量 ]:
208.016251

[ PSA ]:
95.96000

[ LogP ]:
0.87

[ 外观性状 ]:
黄色至褐色粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.641

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
insoluble

一硫化四甲基秋兰姆MSDS

一硫化四甲基秋兰姆毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WQ1750000

CHEMICAL NAME :: Sulfide, bis(dimethylthiocarbamoyl)

CAS REGISTRY NUMBER :: 97-74-5

BEILSTEIN REFERENCE NO. :: 1775650

LAST UPDATED :: 199806

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C6-H12-N2-S3

MOLECULAR WEIGHT :: 208.38

WISWESSER LINE NOTATION :: 1N1&YUS&SYUS&N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 383 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 818 mg/kg

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in cell count (unspecified)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 520 mg/kg/4W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 900 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 nmol/L

REFERENCE :: SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year: 9(Suppl 2),27,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80220 No. of Facilities: 376 (estimated) No. of Industries: 7 No. of Occupations: 23 No. of Employees: 6032 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80220 No. of Facilities: 803 (estimated) No. of Industries: 18 No. of Occupations: 31 No. of Employees: 40683 (estimated) No. of Female Employees: 5320 (estimated)

一硫化四甲基秋兰姆安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H317-H411

[ 警示性声明 ]:
P273-P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R43;R51/53

[ 安全声明 (欧洲) ]:
S24-S26-S37-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
WQ1750000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
3812100000

一硫化四甲基秋兰姆合成路线

一硫化四甲基秋兰姆上下游产品

一硫化四甲基秋兰姆上游产品

一硫化四甲基秋兰姆下游产品

一硫化四甲基秋兰姆制备

将二硫化四甲基秋兰姆（促进剂TMTD）和氰化钠加入反应釜，再加入水和乙醇，搅拌下升温至40～50℃，进行脱硫反应。反应完全后，降温，静置分层。油层经水洗、分离脱水后，即得成品。

一硫化四甲基秋兰姆海关

[ 海关编码 ]: 3812100000

一硫化四甲基秋兰姆文献

New antimony(III) halide complexes with dithiocarbamate ligands derived from thiuram degradation: The effect of the molecule's close contacts on in vitro cytotoxic activity.

Mater. Sci. Eng. C. Mater. Biol. Appl. 58 , 396-408, (2015)

Antimony(III) halide complexes of the formulae {[SbBr(Me2DTC)2]n} (1), {[SbI(Me2DTC)2]n} (2) and {[(Me2DTC)2Sb(μ2-I)Sb(Me2DTC)2](+).I3(-)} (3) (Me2DTC = dimethyldithiocarbomate) were synthesized from ...

Occupational allergic contact dermatitis of the ears caused by thiurams in a headset.

Contact Dermatitis 65(4) , 242-3, (2011)

Enzyme inhibition as a possible mechanism of the mutagenicity of dithiocarbamic acid derivatives in Salmonella typhimurium.

Chem. Biol. Interact. 49(3) , 329-40, (1984)

In recent years data have accumulated regarding genotoxic properties of dithiocarbamic acid derivatives. The results from the present work indicate that the mutagenicity of these compounds depends on ...

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