1,2,4-三甲苯

1,2,4-三甲苯用途

【用途一】
用于生产PVC塑料增塑剂偏苯三酸三辛酯、粉末涂料、电机耐温绝缘漆等
【用途二】
本品为基本有机化工原料，可用于生产医药（维生素E）、染料与合成树脂。还可制偏苯三酸酐、均苯四甲酸二酐、水溶性醇酸树脂、不饱和聚酯树脂以及增塑剂、环氧树脂固化剂及表面活性剂。
【用途三】
用于生产医药（维生素E）、染料、合成树脂及双氧水。

1,2,4-三甲苯名称

[ CAS 号 ]:
95-63-6

[ 中文名 ]:
1,2,4-三甲基苯

[ 英文名 ]:
1,2,4-TRIMETHYL BENZENE

[中文别名 ]:

[英文别名 ]:

EINECS 202-436-9
1,2,4-Trimethylbenzene
1,2,4-trimethyl benzene
MFCD00008527
Pseudoaspidinol-iB
pseudo-cymene
Pseudocumol
pseudocumene

1,2,4-三甲苯物理化学性质

[ 密度 ]:
0.88

[ 沸点 ]:
168 °C(lit.)

[ 熔点 ]:
-44 °C

[ 分子式 ]:
C₉H₁₂

[ 分子量 ]:
120.19200

[ 闪点 ]:
120 °F

[ 精确质量 ]:
120.09400

[ LogP ]:
2.61180

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
4.1 (vs air)

[ 蒸汽压 ]:
4.5 mm Hg ( 37.7 °C)

[ 折射率 ]:
n20/D 1.504(lit.)

[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Flammable. May form explosive mixtures with air.

1,2,4-三甲苯MSDS

1,2,4-三甲苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC3325000

CHEMICAL NAME :: Benzene, 1,2,4-trimethyl-

CAS REGISTRY NUMBER :: 95-63-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C9-H12

MOLECULAR WEIGHT :: 120.21

WISWESSER LINE NOTATION :: 1R B1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,34,1986

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(5),15,1979

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1752 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1258,1989

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1788 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 9,227,1954 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/4W-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year: 1(3),67,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6400 mg/kg/8W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - recording from afferent nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 13,123,1993

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/m3/24H/17W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(5),15,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - B0044 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 13 No. of Employees: 3186 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - B0044 No. of Facilities: 3684 (estimated) No. of Industries: 47 No. of Occupations: 42 No. of Employees: 65953 (estimated) No. of Female Employees: 9768 (estimated)

1,2,4-三甲苯安全信息

[ 符号 ]:

GHS02, GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H304-H315-H319-H332-H335-H411

[ 警示性声明 ]:
P261-P273-P301 + P310-P305 + P351 + P338-P331

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R10;R20;R36/37/38;R51/53

[ 安全声明 (欧洲) ]:
S26-S61-S45-S36/37-S16-S7

[ 危险品运输编码 ]:
UN 3295 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
DC3325000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

1,2,4-三甲苯合成路线

1,2,4-三甲苯上下游产品

1,2,4-三甲苯上游产品

1,2,4-三甲苯下游产品

1,2,4-三甲苯制备

催化重整或石脑油裂解所得C9-C10芳烃中，均含有混合三甲苯，如1,2,4-三甲苯。以重整芳烃为例，其中1,2,4-三甲苯含量高达40%以上。采用蒸馏的方法可以得到纯度99%以上的产品，例如采用两座浮阀塔（共200层）从重整芳烃中分离1,2,4-三甲苯，纯度95-97%，收率58-78%。

1,2,4-三甲苯文献

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

Developmental toxicity of two trimethylbenzene isomers, mesitylene and pseudocumene, in rats following inhalation exposure.

Food Chem. Toxicol. 43(7) , 1055-63, (2005)

The developmental toxicity of two trimethylbenzene isomers, mesitylene (1,3,5-trimethylbenzene) and pseudocumene (1,2,4-trimethylbenzene) was studied in Sprague-Dawley rats following inhalation exposu...

Kinetics and mechanism of the reaction of OH with the trimethylbenzenes--experimental evidence for the formation of adduct isomers.

Phys. Chem. Chem. Phys. 14(40) , 13933-48, (2012)

The reversible gas-phase addition of OH radicals to the trimethylbenzenes was investigated in pulsed experiments utilizing VUV flash-photolysis resonance-fluorescence of H(2)O in the temperature range...

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