<生产厂家价格>

苯亚甲基苯乙酮

苯亚甲基苯乙酮用途

Chalcone 是从甘草中分离得到的,用于合成查耳酮衍生物。Chalcone 具有多种生物活性和药理活性,包括抗炎、抗氧化、抗菌、抗癌、抗寄生虫等活性。

苯亚甲基苯乙酮名称

[ CAS 号 ]:
94-41-7

[ 中文名 ]:
苯亚甲基苯乙酮

[ 英文名 ]:
1,3-Diphenyl-2-propen-1-one

[中文别名 ]:

[英文别名 ]:

EINECS 202-330-2
BENZALACETOPHENONE
benzylidene acetophenone
CHALKONE
MFCD00003082
Cinnamophenone
CHALCONE
PhCOCH=CHPh
styrylphenylketone

苯亚甲基苯乙酮生物活性

[ 描述 ]:

Chalcone 是从甘草中分离得到的,用于合成查耳酮衍生物。Chalcone 具有多种生物活性和药理活性,包括抗炎、抗氧化、抗菌、抗癌、抗寄生虫等活性。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[体外研究]

查尔酮衍生物是由Claisen-Shimidt碱催化适当的芳香酮或取代芳香酮与苯甲醛或取代苯甲醛缩合合成的[1]。

[参考文献]

[1]. Shailendra Mandge,et al. Synthesis and Characterization of Some Chalcone Derivatives. Trends in Applied Sciences Research Volume 2 (1): 52-56, 2007

苯亚甲基苯乙酮物理化学性质

[ 沸点 ]:
208 °C25 mm Hg(lit.)

[ 熔点 ]:
55-59 °C

[ 分子式 ]:
C₁₅H₁₂O

[ 分子量 ]:
208.25500

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
208.08900

[ PSA ]:
17.07000

[ LogP ]:
3.58270

[ 外观性状 ]:
淡黄色斜方或棱形结晶。熔点57-58℃，沸点345-348℃（微分解），相对密度1.0712（62/4℃），折光率（nD62）1.6458，易溶于醚、氯仿、二硫化碳和苯，微溶于醇，难溶于冷石油醚。

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
易溶于：乙醚,氯仿,苯；微溶：醇

苯亚甲基苯乙酮MSDS

苯亚甲基苯乙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL6900000

CHEMICAL NAME :: Chalcone

CAS REGISTRY NUMBER :: 94-41-7

LAST UPDATED :: 199706

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H12-O

MOLECULAR WEIGHT :: 208.27

WISWESSER LINE NOTATION :: RV1U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 681 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 250 units/L

REFERENCE :: ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 35,629,1964

苯亚甲基苯乙酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
R22:Harmful if swallowed. R36/37:Irritating to eyes and respiratory system .

[ 安全声明 (欧洲) ]:
S22-S36/37/39-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UD5576750

[ 海关编码 ]:
2914399090

苯亚甲基苯乙酮合成路线

苯亚甲基苯乙酮上下游产品

苯亚甲基苯乙酮上游产品

苯亚甲基苯乙酮下游产品

苯亚甲基苯乙酮制备

将氢氧化钠溶液和乙醇的混合物冷却、激烈搅拌，加入新蒸的苯乙酮和苯甲醛，在15-30℃搅拌2-3h，反应物逐渐稠化，置冷冻过液，析出黄色沉淀，过滤，洗涤至中性，用乙醇重结晶，得查耳酮，产率84%。

苯亚甲基苯乙酮海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

苯亚甲基苯乙酮文献

Antimycobacterial and anti-inflammatory activities of substituted chalcones focusing on an anti-tuberculosis dual treatment approach.

Molecules 20 , 8072-93, (2015)

Tuberculosis (TB) remains a serious public health problem aggravated by the emergence of M. tuberculosis (Mtb) strains resistant to multiple drugs (MDR). Delay in TB treatment, common in the MDR-TB ca...

Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations.

Molecules 17(11) , 12925-37, (2012)

A high performance liquid chromatographic (HPLC) method with diode array detection (DAD) was established for simultaneous determination of seven main bioactive components in San-ao decoction and its s...

Development of a stability-indicating LC method for determination of a synthetic chalcone derivative in a nanoemulsion dosage form and identification of the main photodegradation product by LC-MS.

J. Pharm. Biomed. Anal. 70 , 652-6, (2012)

This study aimed to develop and validate a stability indicating LC for the determination of 5-(2-benzoylethenyl)-N-benzyl-2 methoxybenzenesulfonamide (SCD - a synthetic chalcone derivative), and evalu...

更多文献