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2-乙氧基苯甲酰胺

2-乙氧基苯甲酰胺用途

2-Ethoxybenzamide广泛用作解热止痛药。

2-乙氧基苯甲酰胺名称

[ CAS 号 ]:
938-73-8

[ 中文名 ]:
2-乙氧基苯甲酰胺

[ 英文名 ]:
2-Ethoxybenzamide

[中文别名 ]:

[英文别名 ]:

2-Ethoxyphenylformamide
2-ethoxy-benzoic acid amide
Etamide
Ethosalicyl
Aethylaethersalicylsaeure-amid
Benzamide,2-ethoxy
2-Aethoxy-benzamid
EINECS 213-346-4
4-10-00-00175 (Beilstein Handbook Reference)
Pirosolvina

2-乙氧基苯甲酰胺生物活性

[ 描述 ]:

2-Ethoxybenzamide广泛用作解热止痛药。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

2-乙氧基苯甲酰胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
302.0±25.0 °C at 760 mmHg

[ 熔点 ]:
129-134 °C

[ 分子式 ]:
C₉H₁₁NO₂

[ 分子量 ]:
165.189

[ 闪点 ]:
153.7±19.5 °C

[ 精确质量 ]:
165.078979

[ PSA ]:
52.32000

[ LogP ]:
1.40

[ 外观性状 ]:
白色或近乎于白色结晶粉末近乎于无气味

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.538

[ 储存条件 ]:
室温

[ 水溶解性 ]:
<0.1 g/100 mL at 16 ºC

2-乙氧基苯甲酰胺MSDS

2-乙氧基苯甲酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV4900000

CHEMICAL NAME :: Benzamide, o-ethoxy-

CAS REGISTRY NUMBER :: 938-73-8

BEILSTEIN REFERENCE NO. :: 2208582

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C9-H11-N-O2

MOLECULAR WEIGHT :: 165.21

WISWESSER LINE NOTATION :: ZVR BO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2630 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 544 gm/kg/54W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: Morphological transformation

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 500 mg/L

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (96),55,1978

2-乙氧基苯甲酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CU4381000

[ 海关编码 ]:
29242995

2-乙氧基苯甲酰胺合成路线

2-乙氧基苯甲酰胺上下游产品

2-乙氧基苯甲酰胺上游产品

2-乙氧基苯甲酰胺下游产品

2-乙氧基苯甲酰胺制备

由水杨酰胺（C7H7NO2，[65-45-2]）经乙基化而得。将水杨酰胺、固体氢氧化钠、乙醇置于反就锅内，密闭升温至60-70℃，搅拌30min，冷却至30℃，加入溴乙烷，再密闭升温至80-100℃，压力不超过0.2MPa，反应3h。降至常压，pH应在8.5以上。趁热过滤，滤渣溴化钠回收。滤液蒸出大部分乙醇后，加蒸馏水析出白色结晶。过滤，水洗至中性，干燥，得邻乙氧基苯甲酰胺。收率约75%。也可采用氯乙烷代替溴乙烷进行乙基化反应，但需要较高压力。

2-乙氧基苯甲酰胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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