1,8-二氨基-3,6-二氧杂辛烷

1,8-二氨基-3,6-二氧杂辛烷用途

PROTAC Linker 19 是一种 PROTAC 连接桥,属于 alkyl/ether 类。PROTAC Linker 19 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过连接桥连接的不同配体; 一种是 E3 泛素连接酶配体,另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

1,8-二氨基-3,6-二氧杂辛烷名称

[ CAS 号 ]:
929-59-9

[ 中文名 ]:
1,8-二氨基-3,6-二氧杂辛烷

[ 英文名 ]:
ethylene glycol bis(2-aminoethyl) ether

[中文别名 ]:

[英文别名 ]:

2,2′-(ethylenedioxy)bis(ethylamine)
1,8-diaminotriethyleneglycol
MFCD00040474
2,2'-[1,2-Ethanediylbis(oxy)]diethanamine
2,2'-[ethane-1,2-diylbis(oxy)]diethanamine
1,2-Bis(2-aminoethoxy)ethane
UNII-R41ZT4UF34
Jeffamine® EDR-176
EDR-148
TRIETHYLENEGLYCOLDIAMINE

1,8-二氨基-3,6-二氧杂辛烷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl/ether

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

1,8-二氨基-3,6-二氧杂辛烷物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
241.0±20.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₁₆N₂O₂

[ 分子量 ]:
148.203

[ 闪点 ]:
104.3±15.5 °C

[ 精确质量 ]:
148.121185

[ PSA ]:
70.50000

[ LogP ]:
-1.59

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.460

[ 储存条件 ]:
室温，密封

1,8-二氨基-3,6-二氧杂辛烷MSDS

1,8-二氨基-3,6-二氧杂辛烷安全信息

[ 符号 ]:

GHS05, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H317-H334

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R22;R34;R42/43

[ 安全声明 (欧洲) ]:
S23-S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 2

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2922199090

1,8-二氨基-3,6-二氧杂辛烷合成路线

1,8-二氨基-3,6-二氧杂辛烷上下游产品

1,8-二氨基-3,6-二氧杂辛烷上游产品

1,8-二氨基-3,6-二氧杂辛烷下游产品

1,8-二氨基-3,6-二氧杂辛烷海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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