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福司曲星

福司曲星用途

Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4)

福司曲星名称

[ CAS 号 ]:
87860-39-7

[ 中文名 ]:
福司曲星

[ 英文名 ]:
Fostriecin

[英文别名 ]:

PHOSPHOTRIENIN
FOSTRIECIN SODIUM SALT
cl1565asodiumsalt
FOSTRIECIN
FST
antibioticcl1565asodiumsalt
MFCD01939908
FOSTRIECIN SODIUM
CL-920
ci920sodiumsalt

福司曲星物理化学性质

[ 沸点 ]:
737.9ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₆NaO₉P

[ 分子量 ]:
452.36800

[ 闪点 ]:
400.1ºC

[ 精确质量 ]:
452.12100

[ PSA ]:
166.39000

[ LogP ]:
1.49330

[ 储存条件 ]:
−20°C

福司曲星MSDS

详细MSDS(安全技术说明书)

福司曲星毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0600000

CHEMICAL NAME :: 2H-Pyran-2-one, 5,6-dihydro-6-(3,6,13-trihydroxy-3-methyl-4-(phosphon ooxy)-1,7,9,11- tridecatetraenyl)-, monosodium salt

CAS REGISTRY NUMBER :: 87860-39-7

LAST UPDATED :: 199606

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H27-O9-P.Na

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,921,1986

福司曲星安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UQ0600000

福司曲星文献

Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.

J. Neurosci. 31 , 5512-25, (2011)

An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors,...

Fostriecin-mediated G2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity.

Cancer Res. 58 , 3611-3619, (1998)

Fostriecin, a structurally unique phosphate ester, is presently under evaluation in clinical trials to determine its potential use as an antitumor drug in humans. Fostriecin has been reported as havin...

Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.

FEBS Lett. 416 , 230, (1997)

Fostriecin, an antitumor antibiotic produced by Streptomyces pulveraceus, is a strong inhibitor of type 2A (PP2A; IC50 3.2 nM) and a weak inhibitor of type 1 (PP1; IC50 131 microM) serine/threonine pr...

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