Safracin B

Safracin B用途

Safracin B 是一种四氢异喹啉 (THIQ) 生物碱,是来自荧光假单胞菌的天然抗生素 (antibiotic)。Safracin B 具有广谱抗微生物和强大的抗肿瘤活性。

Safracin B名称

[ CAS 号 ]:
87578-99-2

[ 英文名 ]:
Safracin B

Safracin B生物活性

[ 描述 ]:

Safracin B 是一种四氢异喹啉 (THIQ) 生物碱,是来自荧光假单胞菌的天然抗生素 (antibiotic)。Safracin B 具有广谱抗微生物和强大的抗肿瘤活性。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

[体内研究]

Safracin B(0.005-5 mg/kg/天；持续9天)可延长荷瘤小鼠的寿命,并对体重为19-24 g的雌性BALB/c x DBA/2 F1(CD2F1)小鼠的L1210和P388白血病及B16黑色素瘤具有抗肿瘤活性[2]。ip给药正常CD2F1小鼠的LD50为7.3 mg/kg,safracin B的LD50为7.3 mg/kg[2]。

[参考文献]

[1]. Gong-Li Tang, et al.Biosynthesis of Tetrahydroisoquinoline Antibiotics. Curr Top Med Chem. 2016;16(15):1717-26.

[2]. T Okumoto, et al. Activity of Safracins A and B, Heterocyclic Quinone Antibiotics, on Experimental Tumors in Mice. J Antibiot (Tokyo). 1985 Jun;38(6):767-71.

Safracin B物理化学性质

[ 分子式 ]:
C₂₈H₃₆N₄O₇

[ 分子量 ]:
540.60800

[ 精确质量 ]:
540.25800

[ PSA ]:
154.66000

[ LogP ]:
1.18090

Safracin B毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TX1404550

CHEMICAL NAME :: Propanamide, 2-amino-N-((6,7,9,10,13,14,14a,15-octahydro-1,7-dihyd roxy-2,11-dimethoxy- 3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino( 3,2-b)(3)benzazocin-9 -yl)methyl)-

CAS REGISTRY NUMBER :: 87578-99-2

LAST UPDATED :: 199401

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C28-H36-N4-O7

MOLECULAR WEIGHT :: 540.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3540 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #83-113192