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6-氨基尿嘧啶

6-氨基尿嘧啶用途

【用途一】
用作医药咖啡因、茶碱、SDM等中间体

6-氨基尿嘧啶名称

[ CAS 号 ]:
873-83-6

[ 中文名 ]:
4-氨基-2,6-二羟基嘧啶

[ 英文名 ]:
6-Aminouracil

[中文别名 ]:

[英文别名 ]:

4-Amino-2,6-dihydroxypyrimidine
6-Amino-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 6-amino-
4-AMINOURACI
6-amino-1H-pyrimidine-2,4-dione
MFCD00006071
6-aminopyrimidine-2,4-diol
Pyrimidine, 2,4-dihydroxy-6-amino
4-ADHP
EINECS 212-854-3

6-氨基尿嘧啶物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
580.4±53.0 °C at 760 mmHg

[ 熔点 ]:
≥360 °C(lit.)

[ 分子式 ]:
C₄H₅N₃O₂

[ 分子量 ]:
127.101

[ 闪点 ]:
304.8±30.9 °C

[ 精确质量 ]:
127.038177

[ PSA ]:
91.74000

[ LogP ]:
-2.33

[ 外观性状 ]:
细灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.746

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
slightly soluble

6-氨基尿嘧啶MSDS

6-氨基尿嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ8750000

CHEMICAL NAME :: Uracil, 6-amino-

CAS REGISTRY NUMBER :: 873-83-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H5-N3-O2

MOLECULAR WEIGHT :: 127.12

WISWESSER LINE NOTATION :: T6MVMVJ FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,696,1955

6-氨基尿嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YQ8750000

[ 海关编码 ]:
29335995

6-氨基尿嘧啶合成路线

6-氨基尿嘧啶上下游产品

6-氨基尿嘧啶上游产品

6-氨基尿嘧啶下游产品

6-氨基尿嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-氨基尿嘧啶文献

Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.

Mini Rev. Med. Chem. 5(12) , 1113-23, (2005)

Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolys...

Synthesis of 6-aminouracils and pyrrolo[2,3-d]pyrimidine-2,4-diones and their inhibitory effect on thymidine phosphorylase.

Nucleic Acids Symp. Ser. (37) , 59-60, (1997)

Inhibitors of thymidine phosphorylase (dThdPase) are expected to suppress the growth and metastasis of tumor cells by inhibition of angiogenesis and were designed by utilizing the three dimensional st...

Synthesis, chemical and pharmacological properties of some 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido [4,5-d]pyrimidines.

Acta Pol. Pharm. 53(1) , 39-46, (1996)

Synthesis of 6-substituted 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidines [III-VI] obtained by cyclocondensation of 1-phenyl-6-aminouracil with formaline and the primary amines is descr...

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