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Nylidrin Hydrochloride

Nylidrin Hydrochloride用途

Nylidrin hydrochloride 是被动致敏大鼠腹腔肥大细胞中IgE介导的组胺释放抑制剂，具有抗过敏的功效。

Nylidrin Hydrochloride名称

[ CAS 号 ]:
849-55-8

[ 中文名 ]:
布芬宁盐酸盐

[ 英文名 ]:
Nylidrin hydrochloride

[中文别名 ]:

盐酸布酚宁

[英文别名 ]:

Nylidrin,HCl
Buphedrin
Dilatol
EINECS 212-701-0
MFCD00035085
Arlibide
arlidinhydrochloride
dilatyl
dilatolhydrochloride
Arlidin

Nylidrin Hydrochloride生物活性

[ 描述 ]:

Nylidrin hydrochloride 是被动致敏大鼠腹腔肥大细胞中IgE介导的组胺释放抑制剂,具有抗过敏的功效。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. A Khandwala, et al. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). I. Effect on release of histamine in vitro from rat peritoneal mast cells, guinea pig lung slices and human basophils. International Archives of Allergy & Applied Immunology, 1983, 70 (4)

Nylidrin Hydrochloride物理化学性质

[ 熔点 ]:
111ºC

[ 分子式 ]:
C₁₉H₂₆ClNO₂

[ 分子量 ]:
335.86800

[ 精确质量 ]:
335.16500

[ PSA ]:
52.49000

[ LogP ]:
4.61790

[ 外观性状 ]:
粉末

[ 储存条件 ]:
-20℃

Nylidrin Hydrochloride毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO8300000

CHEMICAL NAME :: Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)et hyl)-, hydrochloride

CAS REGISTRY NUMBER :: 849-55-8

LAST UPDATED :: 199504

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C19-H25-N-O2.Cl-H

MOLECULAR WEIGHT :: 335.91

WISWESSER LINE NOTATION :: QR DYQY1&MY1&2R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,538,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,351,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3542870

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,351,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 24,431,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,351,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6178 No. of Facilities: 36 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 357 (estimated) No. of Female Employees: 187 (estimated)

Nylidrin Hydrochloride安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
36

[ WGK德国 ]:
3

[ RTECS号 ]:
DO8300000