<生产厂家价格>

毒黄素

毒黄素用途

Toxoflavin (Xanthothricin) 是一种 TCF4/β-catenin 复合物抑制剂,也是一种 KDM4A 抑制剂,具有抗肿瘤活性。

毒黄素名称

[ CAS 号 ]:
84-82-2

[ 中文名 ]:
毒黄素

[ 英文名 ]:
Toxoflavin

[英文别名 ]:

Toxoflavin
Xanthotricin
Xanthothricin (VAN)
Compound 7215
Toxoflavine
Xanthothricin
GNF-Pf-67

毒黄素生物活性

[ 描述 ]:

Toxoflavin (Xanthothricin) 是一种 TCF4/β-catenin 复合物抑制剂,也是一种 KDM4A 抑制剂,具有抗肿瘤活性。

[ 相关类别 ]:

研究领域 >> 癌症

[ 靶点 ]

TCF4/β-catenin[1], KDM4A[2]

[体外研究]

toxoflavin(黄腐霉素)对3种肝癌细胞株具有剂量依赖性细胞毒性,Hep40细胞、HepG2细胞和Huh7细胞的IC50s分别为0.66μm、0.36μm和0.98μm[1]。

[参考文献]

[1]. Wei W, et al. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer. 2010 May 15;126(10):2426-36.

[2]. Franci G, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics. 2017 Mar 4;12(3):198-205.

毒黄素物理化学性质

[ 密度 ]:
1.65g/cm3

[ 沸点 ]:
276.7ºC at 760 mmHg

[ 分子式 ]:
C₇H₇N₅O₂

[ 分子量 ]:
193.16300

[ 闪点 ]:
121.1ºC

[ 精确质量 ]:
193.06000

[ PSA ]:
82.67000

[ 折射率 ]:
1.76

[ 储存条件 ]:
-20°C，密闭，干燥

毒黄素MSDS

详细MSDS(安全技术说明书)

毒黄素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7875000

CHEMICAL NAME :: Pyrimido(5,4-e)-as-triazine-5,7-(1H,6H)-dione, 1,6-dimethyl-

CAS REGISTRY NUMBER :: 84-82-2

BEILSTEIN REFERENCE NO. :: 0021014

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H7-N5-O2

MOLECULAR WEIGHT :: 193.19

WISWESSER LINE NOTATION :: T66 BVNVN GNN JNJ C1 G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 ug/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria Gastrointestinal - hypermotility, diarrhea Sense Organs and Special Senses (Eye) - lacrimation

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,259,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 31,900,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - hematuria

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,259,1954

毒黄素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2933990090

毒黄素海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

毒黄素文献

Investigations into the Biosynthesis, Regulation, and Self-Resistance of Toxoflavin in Pseudomonas protegens Pf-5.

ChemBioChem. 16 , 1782-90, (2015)

Pseudomonas spp. are prolific producers of natural products from many structural classes. Here we show that the soil bacterium Pseudomonas protegens Pf-5 is capable of producing trace levels of the tr...

The quorum sensing-dependent gene katG of Burkholderia glumae is important for protection from visible light.

J. Bacteriol. 191(13) , 4152-7, (2009)

Quorum sensing (QS) plays important roles in the pathogenicity of Burkholderia glumae, the causative agent of bacterial rice grain rot. We determined how QS is involved in catalase expression in B. gl...

Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation.

J. Am. Chem. Soc. 134(11) , 5326-30, (2012)

Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR an...

更多文献

毒黄素