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2,3-二苯酚丁二烯

2,3-二苯酚丁二烯用途

Dienestrol是一种合成的, 非甾体类雌激素, 是一种雌激素受体激动剂, 治疗对绝经期和绝经后症状。

2,3-二苯酚丁二烯名称

[ CAS 号 ]:
84-17-3

[ 中文名 ]:
双烯雌酚

[ 英文名 ]:
Dienestrol

[中文别名 ]:

[英文别名 ]:

Retalon
Oestrora
Dinestrol
MFCD00050983
Isodienoestrol
Agaldog
Sexadien
Estroral
Dienoestrol
EINECS 201-519-7

2,3-二苯酚丁二烯生物活性

[ 描述 ]:

Dienestrol是一种合成的, 非甾体类雌激素, 是一种雌激素受体激动剂, 治疗对绝经期和绝经后症状。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 内分泌

[相关活性小分子]

2,3-二苯酚丁二烯物理化学性质

[ 密度 ]:
1.129 g/cm3

[ 沸点 ]:
395.4ºC at 760 mmHg

[ 熔点 ]:
229ºC

[ 分子式 ]:
C₁₈H₁₈O₂

[ 分子量 ]:
266.33400

[ 闪点 ]:
181.4ºC

[ 精确质量 ]:
266.13100

[ PSA ]:
40.46000

[ LogP ]:
4.60460

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystal

[ 折射率 ]:
1.4800 (estimate)

[ 储存条件 ]:
2-8°C

2,3-二苯酚丁二烯MSDS

详细MSDS(安全技术说明书)

2,3-二苯酚丁二烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL0580000

CHEMICAL NAME :: Phenol, 4,4'-(diethylideneethylene)di-

CAS REGISTRY NUMBER :: 84-17-3

LAST UPDATED :: 199512

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C18-H18-O2

MOLECULAR WEIGHT :: 266.36

WISWESSER LINE NOTATION :: QR DYU2&YU2&R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 ug/kg

SEX/DURATION :: female 3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 75 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,31,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,278,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83633 No. of Facilities: 124 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 2882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83633 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)

2,3-二苯酚丁二烯安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H350-H361

[ 警示性声明 ]:
P201-P280-P308 + P313

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S22;S24/25

[ 危险品运输编码 ]:
2811.0

[ WGK德国 ]:
3

[ RTECS号 ]:
SL0580000

[ 危险类别 ]:
6.1

2,3-二苯酚丁二烯文献

Graphene oxide-based microspheres for the dispersive solid-phase extraction of non-steroidal estrogens from water samples.

J. Chromatogr. A. 1368 , 18-25, (2014)

A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was develo...

Packed-fiber solid-phase extraction coupled with high performance liquid chromatography–tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 7-13, (2014)

• A method based on packed-fiber solid-phase extraction (PF SPE) has been established for the determination of three estrogenic stilbenes in dairy products. • Samples were pretreated with PF SPE using...

Quantitative determination of 26 steroids in eggs from various species using liquid chromatography-triple quadrupole-mass spectrometry.

J. Chromatogr. A. 1356 , 54-63, (2014)

A method for analyzing 26 types of steroids in egg matrix was developed. The method used liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in electrospray ionization mode (ESI). T...

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