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金黄霉素B

金黄霉素B用途

金霉素B是从链霉菌中分离出来的一种抗生素。金霉素B对人肺腺癌A549细胞株DNA损伤及拓扑异构酶II的抑制作用。金霉素B抑制小鼠移植性肿瘤的生长。

金黄霉素B名称

[ CAS 号 ]:
83852-56-6

[ 中文名 ]:
金黄霉素B

[ 英文名 ]:
Chrysomycin B

[英文别名 ]:

金黄霉素B生物活性

[ 描述 ]:

金霉素B是从链霉菌中分离出来的一种抗生素。金霉素B对人肺腺癌A549细胞株DNA损伤及拓扑异构酶II的抑制作用。金霉素B抑制小鼠移植性肿瘤的生长。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

金黄霉素B物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
784.0±60.0 °C at 760 mmHg

[ 分子式 ]:
C₂₇H₂₈O₉

[ 分子量 ]:
496.506

[ 闪点 ]:
265.9±26.4 °C

[ 精确质量 ]:
496.173340

[ PSA ]:
138.82000

[ LogP ]:
4.99

[ 外观性状 ]:
solid

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.663

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMF: soluble

金黄霉素B安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

金黄霉素B文献

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.

Nat. Prod. Rep. 29(2) , 264-325, (2012)

Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativit...

A colorimetric microassay for the detection of agents that interact with DNA.

J. Nat. Prod. 55(11) , 1582-7, (1992)

A simple microtiter assay for the detection of compounds that bind DNA is described. Agents that displace methyl green from DNA are detected spectrophotometrically by a decrease in absorbance at 630 n...

The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A.

J. Antibiot. 35(9) , 1194-201, (1982)

The yellow antibiotic chrysomycin, isolated in crystalline form in 1955, is found to consist of two closely related components, a major one, chrysomycin A, and a minor one, chrysomycin B. They differ ...

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