GYKI-23107

GYKI-23107用途

GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity. GYKI-23107 was effective against chemically (aconitine and ouabain) induced arrhythmias after both parenteral and oral administration. GYKI-23107 and mexiletine produced similar elevation of the fibrillation threshold in anaesthetized cats. After oral pretreatment, GYKI-23107 showed protective effects against coronary ligation-induced arrhythmia in conscious rats. The circulatory side-effects of GYKI-23107 in anaesthetized and conscious dogs and cats were milder then those of mexiletine.

GYKI-23107名称

[ CAS 号 ]:
83843-39-4

[ 英文名 ]:
GYKI-23107

GYKI-23107物理化学性质

[ 沸点 ]:
312.5ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₂₄Cl₂N₂

[ 分子量 ]:
279.24900

[ 闪点 ]:
117.5ºC

[ 精确质量 ]:
278.13200

[ PSA ]:
15.27000

[ LogP ]:
4.34240

GYKI-23107毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TX8032260

CHEMICAL NAME :: 1,2-Propanediamine, N(sup 2),N(sup 2)-dimethyl-N(sup 1)-2,6-xylyl-, dihydrochloride

CAS REGISTRY NUMBER :: 83843-39-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H22-N2.2Cl-H

MOLECULAR WEIGHT :: 279.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 114 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987