溴代氯乙腈

溴代氯乙腈用途

Bromochloroacetonitrile 是含天然有机物水的氯消毒副产物。Bromochloroacetonitrile 具有直接致突变活性,能诱导 DNA 链断裂。

溴代氯乙腈名称

[ CAS 号 ]:
83463-62-1

[ 中文名 ]:
溴代氯乙腈

[ 英文名 ]:
UNII:SHY3J1BBQ6

[中文别名 ]:

溴氯乙腈

[英文别名 ]:

Acetonitrile, 2-bromo-2-chloro-
BROMOCHLOROACETONITRILE
Bromo(chloro)acetonitrile
UNII:SHY3J1BBQ6
2-bromo-2-chloroacetonitrile

溴代氯乙腈生物活性

[ 描述 ]:

Bromochloroacetonitrile 是含天然有机物水的氯消毒副产物。Bromochloroacetonitrile 具有直接致突变活性,能诱导 DNA 链断裂。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

研究领域 >> 其他

[体外研究]

溴氯乙腈(BCAN)诱导中国仓鼠卵巢细胞姐妹染色单体互换[1]。

[参考文献]

[1]. Suzanne A. et al.The developmental toxicity of bromochloroacetonitrile in pregnant long‐evans rats, International Journal of Environmental Health Research, 5:2, 175-188.

溴代氯乙腈物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
121.1±20.0 °C at 760 mmHg

[ 分子式 ]:
C₂HBrClN

[ 分子量 ]:
154.393

[ 闪点 ]:
27.1±21.8 °C

[ 精确质量 ]:
152.898087

[ PSA ]:
23.79000

[ LogP ]:
1.23

[ 蒸汽压 ]:
14.8±0.2 mmHg at 25°C

[ 折射率 ]:
1.507

[ 储存条件 ]:
库房通风干燥低温

溴代氯乙腈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AL8010000

CHEMICAL NAME :: Acetonitrile, bromochloro-

CAS REGISTRY NUMBER :: 83463-62-1

LAST UPDATED :: 199607

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C2-H-Br-Cl-N

MOLECULAR WEIGHT :: 154.40

WISWESSER LINE NOTATION :: NCYGE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg/2W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 825 mg/kg

SEX/DURATION :: female 7-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 845 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 585 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 65 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 4200 nmol/L

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,1065,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991

溴代氯乙腈安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R23/24/25;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 1760

[ RTECS号 ]:
AL8010000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2926909090

溴代氯乙腈合成路线

详细合成路线

溴代氯乙腈海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%