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D609 钾盐

D609 钾盐用途

D609 是一种选择性的磷脂酰胆碱特异性的磷脂酶C (phosphatidyl choline-specific phospholipase C) 抑制剂，K_i 值为 6.4 μM，常用于抗病毒和抗肿瘤研究。

D609 钾盐名称

[ CAS 号 ]:
83373-60-8

[ 中文名 ]:
D609 钾盐

[ 英文名 ]:
D609

[中文别名 ]:

D609钾盐

[英文别名 ]:

Tricyclodecan-9-yl xanthate potassium salt
D609
TRICYCLODECAN-9-YL XANTHOGENATE K
tricyclodecane-9-yl-xanthogenate
D-609 POTASSIUM
Tricyclodecan-9-yl xanthate
MFCD00171401
EINECS 280-379-9
D609 POTASSIUM SALT
Tricyclodecan-9-yl xanthogenate

D609 钾盐生物活性

[ 描述 ]:

D609 是一种选择性的磷脂酰胆碱特异性的磷脂酶C (phosphatidyl choline-specific phospholipase C) 抑制剂,Ki 值为 6.4 μM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷脂

研究领域 >> 癌症

[ 靶点 ]

Ki: 6.4 μM (PC-PLC)

[参考文献]

[1]. Kalluri HS, et al. D609 inhibits the proliferation of neural progenitor cells.Neuroreport. 2010 Jul 14;21(10):700-3.

[2]. Milhas D, et al. The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes.Int J Mol Sci. 2012;13(7):8834-52. Epub 2012 Jul 16.

[3]. Gusain A, et al. Anti-proliferative effects of tricyclodecan-9-yl-xanthogenate (D609) involve ceramide and cell cycle inhibition.Mol Neurobiol. 2012 Jun;45(3):455-64. Epub 2012 Mar 14.

[相关活性小分子]

D609 钾盐物理化学性质

[ 密度 ]:
1.24 g/cm3

[ 沸点 ]:
303.8ºC at 760 mmHg

[ 分子式 ]:
C₁₁H₁₅KOS₂

[ 分子量 ]:
266.465

[ 闪点 ]:
137.5ºC

[ 精确质量 ]:
266.020142

[ PSA ]:
66.62000

[ LogP ]:
3.31010

[ 外观性状 ]:
灰白色粉末

[ 储存条件 ]:
2-8℃

D609 钾盐MSDS

详细MSDS(安全技术说明书)

D609 钾盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

D609 钾盐制备

0-6°C冷藏，密闭，干燥处

D609 钾盐文献

Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation.

Biochim. Biophys. Acta 1841(12) , 1672-82, (2015)

Most anti-cancer agents induce apoptosis, however, a development of multidrug resistance in cancer cells and defects in apoptosis contribute often to treatment failure. Here, the mechanism of curcumin...

Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice.

Infect. Immun. 83(2) , 780-91, (2015)

Mycobacterium abscessus is a pathogenic, rapidly growing mycobacterium involved in pulmonary and cutaneo-mucous infections worldwide, to which cystic fibrosis patients are exquisitely susceptible. The...

Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation.

Shock 44 , 157-65, (2015)

Multiorgan failure is a major cause of late mortality following trauma. Oxidative stress generated during shock/resuscitation contributes to tissue injury by priming the immune system for an exaggerat...

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