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利福昔明

利福昔明用途

Rifaximin(Xifaxan)是口服的半合成非系统性抗菌素,来源于利福霉素SV。

利福昔明名称

[ CAS 号 ]:
80621-81-4

[ 中文名 ]:
利福西亚胺

[ 英文名 ]:
Rifaximin

[中文别名 ]:

[英文别名 ]:

Normix
rifaxidin
Xifaxan
RIFAMIXIN
Rifacol
l105sv
Rifaximin
l105
MFCD00864973
fatroximin

利福昔明生物活性

[ 描述 ]:

Rifaximin(Xifaxan)是口服的半合成非系统性抗菌素,来源于利福霉素SV。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Cruciani F, Brigidi P, Calanni F et al. Efficacy of rifaximin vaginal tablets in treatment of bacterial vaginosis: a molecular characterization of the vaginal microbiota. Antimicrob Agents Chemother. 2012 Aug;56(8):4062-70.

[2]. Cremonini F, Lembo A. Rifaximin for the treatment of irritable bowel syndrome. Expert Opin Pharmacother. 2012 Feb;13(3):433-40.

[3]. Rivkin A, Gim S. Rifaximin: new therapeutic indication and future directions. Clin Ther. 2011 Jul;33(7):812-27.

[4]. Cottreau J, Baker SF, DuPont HL, Garey KW. Rifaximin: a nonsystemic rifamycin antibiotic for gastrointestinal infections. Expert Rev Anti Infect Ther. 2010 Jul;8(7):747-60.

[5]. Koo HL, DuPont HL. Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases. Curr Opin Gastroenterol. 2010 Jan;26(1):17-25.

[6]. Ojetti V, Lauritano EC, Barbaro F et al. Rifaximin pharmacology and clinical implications. Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):675-82.

[相关活性小分子]

利福昔明物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
200-205ºC(dec)

[ 分子式 ]:
C₄₃H₅₁N₃O₁₁

[ 分子量 ]:
785.878

[ 精确质量 ]:
785.352356

[ PSA ]:
198.38000

[ LogP ]:
3.22

[ 外观性状 ]:
红色-橙色结晶粉末

[ 折射率 ]:
1.634

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
ethanol: soluble1mg/mL

利福昔明MSDS

利福昔明安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2.0

[ RTECS号 ]:
KD1576000

利福昔明合成路线

利福昔明上下游产品

利福昔明上游产品

利福昔明下游产品

利福昔明文献

Methane biogenesis during sodium azide-induced chemical hypoxia in rats.

Am. J. Physiol. Cell Physiol. 304(2) , C207-14, (2013)

Previous studies demonstrated methane generation in aerobic cells. Our aims were to investigate the methanogenic features of sodium azide (NaN(3))-induced chemical hypoxia in the whole animal and to s...

Effectiveness of different therapeutic strategies in preventing diverticulitis recurrence.

Eur. Rev. Med. Pharmacol. Sci. 17(3) , 342-8, (2013)

Colonic diverticulitis shows a high recurrence rate.To assess the efficacy of three different therapeutic strategies in preventing diverticulitis recurrence.One hundred thirty patients suffering from ...

Combination therapy for the treatment and prevention of hepatic encephalopathy.

Ann. Pharmacother. 46(11) , 1559-63, (2012)

To evaluate the efficacy and safety of combination therapy for the treatment and prevention of hepatic encephalopathy (HE).A PubMed MEDLINE search was conducted (1947-June 2012) using the key terms la...

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利福昔明

利福昔明用途

利福昔明名称

利福昔明生物活性

利福昔明物理化学性质

利福昔明MSDS

详细MSDS(安全技术说明书)

利福昔明安全信息

利福昔明合成路线

详细合成路线

利福昔明上下游产品

利福昔明上游产品

利福昔明下游产品

利福昔明文献

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