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N-乙酰基金刚烷胺

N-乙酰基金刚烷胺用途

1,8-二氨基-p-薄荷烷通常用于各种席夫碱的合成,这些席夫碱用于制备与铜（II）、锌（II）、铬（III）、铁（III）的配位络合物,还用作合成具有除草活性的杂环席夫碱衍生物的前体。

N-乙酰基金刚烷胺名称

[ CAS 号 ]:
80-52-4

[ 中文名 ]:
N-乙酰基金刚烷胺

[ 英文名 ]:
1,8-Diamino-p-menthane

[中文别名 ]:

[英文别名 ]:

4-(2-Amino-2-propanyl)-1-methylcyclohexanamine
Cyclohexanemethanamine, 4-amino-α,α,4-trimethyl-
MFCD00001488
EINECS 201-287-7
4-(2-aminopropan-2-yl)-1-methylcyclohexanamine
1,8-Diamino-p-menthane

N-乙酰基金刚烷胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
246.5±0.0 °C at 760 mmHg

[ 熔点 ]:
−45 °C(lit.)

[ 分子式 ]:
C₁₀H₂₂N₂

[ 分子量 ]:
170.295

[ 闪点 ]:
93.3±0.0 °C

[ 精确质量 ]:
170.178299

[ PSA ]:
52.04000

[ LogP ]:
1.17

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.481

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

N-乙酰基金刚烷胺MSDS

详细MSDS(安全技术说明书)

N-乙酰基金刚烷胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS8925000

CHEMICAL NAME :: p-Menthane-1,8-diamine

CAS REGISTRY NUMBER :: 80-52-4

BEILSTEIN REFERENCE NO. :: 1098767

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H22-N2

MOLECULAR WEIGHT :: 170.34

WISWESSER LINE NOTATION :: L6TJ AZ A1 DXZ1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 770 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 630 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0532 No. of Facilities: 96 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees: 2754 (estimated) No. of Female Employees: 1273 (estimated)

N-乙酰基金刚烷胺安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H314-H331

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S26-S27-S28-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2922 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
OS8925000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

N-乙酰基金刚烷胺合成路线

详细合成路线

N-乙酰基金刚烷胺上下游产品

N-乙酰基金刚烷胺上游产品

N-乙酰基金刚烷胺下游产品

N-乙酰基金刚烷胺制备

（1）3-氰基-3，5，5-三甲基环乙酮在钴、氢气的催化下，与氨气反应合成，反应压强15.2MPa（150atm)，温度120℃。（2）使用3个分子的丙酮缩合成异佛尔酮，进一步用HCN加成异佛尔酮的双键得到异佛尔酮腈（3-氰基-3，5，5-三甲基环乙酮），继续在H2存在下还原和胺化得产品。