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4,4'-二氯-α-甲基二苯基甲醇

4,4'-二氯-α-甲基二苯基甲醇用途

Chlorfenethol 是一种脱氢氯酸酶抑制剂。Chlorfenethol 可作为杀虫剂 DDT 的增效剂,以增强其对抗性菌株的作用。

4,4'-二氯-α-甲基二苯基甲醇名称

[ CAS 号 ]:
80-06-8

[ 中文名 ]:
杀螨醇

[ 英文名 ]:
1,1-Bis(p-chlorophenyl)methyl-carbinol

[中文别名 ]:

[英文别名 ]:

1,1-bis(4-chlorophenyl)ethan-1-ol
MFCD00000628
4,4'-Dichloro-alpha-methylbenzhydrol
EINECS 201-246-3
4,4’-dichloro-α-methylbenzhydryl alcohol
1,1-bis(4-chlorophenyl)ethanol

4,4'-二氯-α-甲基二苯基甲醇生物活性

[ 描述 ]:

Chlorfenethol 是一种脱氢氯酸酶抑制剂。Chlorfenethol 可作为杀虫剂 DDT 的增效剂,以增强其对抗性菌株的作用。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[ 靶点 ]

dehydrochlorinase[1]

[参考文献]

[1]. Maestre-Serrano R, et al. Susceptibility to insecticides and resistance mechanisms in Aedes aegypti from the Colombian Caribbean Region. Pestic Biochem Physiol. 2014 Nov;116:63-73.

[2]. W. R. Halliday, et al. Inheritance of Resistance to Permethrin and DDT in the Southern House Mosquito (Diptera: Culicidae), Journal of Economic Entomology, Volume 78, Issue 4, 1 August 1985, Pages 762–767,

4,4'-二氯-α-甲基二苯基甲醇物理化学性质

[ 熔点 ]:
69-71°C

[ 分子式 ]:
C₁₄H₁₂Cl₂O

[ 分子量 ]:
267.15000

[ 精确质量 ]:
266.02700

[ PSA ]:
20.23000

[ LogP ]:
4.24920

[ 储存条件 ]:
库房通风低温干燥

4,4'-二氯-α-甲基二苯基甲醇MSDS

4,4'-二氯-α-甲基二苯基甲醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC7875000

CHEMICAL NAME :: Benzhydrol, 4,4'-dichloro-alpha-methyl-

CAS REGISTRY NUMBER :: 80-06-8

BEILSTEIN REFERENCE NO. :: 2505345

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H12-Cl2-O

MOLECULAR WEIGHT :: 267.16

WISWESSER LINE NOTATION :: GR DXQ1&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705) Volume(issue)/page/year: 20,8,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,15,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 725 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,148,1968

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 72,304,1949

4,4'-二氯-α-甲基二苯基甲醇安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H411

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S36/37/39-S61-S36

[ 危险品运输编码 ]:
2811

[ RTECS号 ]:
DC7875000

4,4'-二氯-α-甲基二苯基甲醇合成路线

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4,4'-二氯-α-甲基二苯基甲醇文献

Cation modulation of bicelle size and magnetic alignment as revealed by solid-state NMR and electron microscopy.

Biophys. J. 83(5) , 2667-80, (2002)

The influence of salts (KCl, NaCl, CaCl(2), and MgCl(2)) on bicelles (bilayered micelles) made of dimyristoylphosphatidylcholine (DMPC, molar fraction X = 78%) and dicaproylphosphatidylcholine (DCPC) ...

Nonequilibrium phenomena in the phase separation of a two-component lipid bilayer.

Biophys. J. 82(2) , 823-34, (2002)

Lipid bilayers composed of two phospholipids with significant acyl-chain mismatch behave as nonideal mixtures. Although many of these systems are well characterized from the equilibrium point of view,...

Binding of Ca2+ to the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum: equilibrium studies.

Biochem. J. 297 ( Pt 3) , 615-24, (1994)

Equilibrium fluorescence methods have been used to establish a model for Ca2+ binding to the (Ca(2+)-Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum and to define the effects of H+ and Mg2+ on ...

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