磷酸三乙酯

磷酸三乙酯用途

【用途一】
用作高沸点溶剂、橡胶及塑料的增塑剂，也用作制备农药杀虫剂的原料、乙基化试剂等
【用途二】
用作高沸点的溶剂及增塑剂，也用于杀虫剂的制备及防水化合物的配制
【用途三】
该品为高沸点溶剂，橡胶和塑料的增塑剂。也是催化剂。也用作制取农药杀虫剂的原料。以及用作乙基化试剂，用于乙烯酮生产。在日本，该品的70%用于催化剂，约20%用作溶剂。主要用途如下：（1）催化剂二甲苯异构体催化剂；烯烃的聚合催化剂；制造四乙基铅的催化剂；制造碳化二亚胺的催化剂；三烷基硼和烯烃的置换反应催化剂；用乙酸高温脱水制造乙烯酮的催化剂；苯乙烯同共轭二烯类化合物聚合用的催化剂；如果在对苯二甲酸、乙二醇聚合时使用则有防止纤维变色的作用。（2）溶剂硝酸纤维素及乙酸纤维素的溶剂；用于保持有机过氧化物催化剂寿命的溶剂；氟化乙烯分散用的溶剂；作聚酯树脂、环氧树脂的固化催化剂的过氧化物剂及稀释剂。（3）稳定剂氯系杀虫剂和稳定剂；酚醛树脂的稳定剂；糖醇树脂的固体剂。（4）合成树脂方面二甲酚甲醛树脂的固化剂；壳型塑模所使用的酚醛树脂的软化剂；氯乙烯的柔软剂；乙酸乙烯聚合物的增塑剂；聚酯树脂的阻燃剂。
【用途四】
高沸点溶剂，乙烯酮生产催化剂，乙基化试剂，硝酸纤维素及乙酸纤维素的溶剂。

磷酸三乙酯名称

[ CAS 号 ]:
78-40-0

[ 中文名 ]:
磷酸三乙酯(TEP)

[ 英文名 ]:
Triethyl phosphate

[中文别名 ]:

[英文别名 ]:

Phosphoric ether
Phosphoric acid triethyl ester
Triethyl phosphate
AURORA KA-1638
Triethylfosfat
Phosphoric acid, triethyl ester
diethylphosphoric acid ethyl ester
Triethylphosphate
ETHYL ACID PHOSPHATE
MFCD00009077

磷酸三乙酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
219.3±8.0 °C at 760 mmHg

[ 熔点 ]:
-56 °C

[ 分子式 ]:
C₆H₁₅O₄P

[ 分子量 ]:
182.155

[ 闪点 ]:
115.6±0.0 °C

[ 精确质量 ]:
182.070801

[ PSA ]:
54.57000

[ LogP ]:
1.08

[ 外观性状 ]:
透明无色液体

[ 蒸汽密度 ]:
6.28 (vs air)

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.406

[ 储存条件 ]:
室温，干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, water.

[ 水溶解性 ]:
SOLUBLE

磷酸三乙酯MSDS

详细MSDS(安全技术说明书)

磷酸三乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TC7900000

CHEMICAL NAME :: Phosphoric acid, triethyl ester

CAS REGISTRY NUMBER :: 78-40-0

BEILSTEIN REFERENCE NO. :: 1705772

LAST UPDATED :: 199712

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C6-H15-O4-P

MOLECULAR WEIGHT :: 182.18

WISWESSER LINE NOTATION :: 2OPO&O2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1311 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28000 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 485 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >20 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18900 mg/kg/9W-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 360 gm/kg/17W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1786 mg/m3/6H/16D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 57 gm/kg

SEX/DURATION :: female 92 day(s) pre-mating female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: Specific locus test

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 10 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 21,175,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82035 No. of Facilities: 377 (estimated) No. of Industries: 17 No. of Occupations: 24 No. of Employees: 8789 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82035 No. of Facilities: 425 (estimated) No. of Industries: 8 No. of Occupations: 25 No. of Employees: 5855 (estimated) No. of Female Employees: 1898 (estimated)

磷酸三乙酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S25

[ 危险品运输编码 ]:
3278

[ WGK德国 ]:
1

[ RTECS号 ]:
TC7900000

[ 海关编码 ]:
29190090

磷酸三乙酯合成路线

详细合成路线

磷酸三乙酯上下游产品

磷酸三乙酯上游产品

磷酸三乙酯下游产品

磷酸三乙酯制备

（1）由三氯化磷、乙醇与乙酸钠作用制备

①氯化磷酸二乙酯的制备将三氯化磷与甲苯混合后，搅拌下加入无水乙醇，湿度控制在30-40℃加完后继续搅拌0.5h ，反应生成亚磷酸二乙酯。接着再滴入二氯硫酰，湿度管制在30-40℃减压除去多余的二氯硫酰，剩余物即氯代磷酸二乙酯。

②磷酸三乙酯的制备将乙醇钠的醇溶液加入反应釜，在搅拌下滴加氯代磷酸二乙酯，湿度控制在70℃以下，用乙醇钠和乙酸调解pH值至7-8，加完后搅拌4h。然后加入冷水，搅拌均匀后再加入甲苯，继续搅拌一段时间，静置分层，提取上层油状物，用无水碳酸干燥，过滤后回收甲苯，再进行减压蒸馏，收集72-88℃/0.4-0.667MPa的产物，即得成品。

（2）以三氯氧磷和乙醇为原料，两步酯化法合成将100mL(1.07mol)三氯氧磷投入装有搅拌器的250mL四口烧瓶中，用冰盐水冷却至低于15℃然后在真空下滴加92mL（1.60mol)乙醇。在另一带有搅拌器的1000mL四口烧瓶中，投入550mL(9.63mol)乙醇，常压下滴加上述产物，用冰盐水水冷却，保证反应湿度小于15℃将反应混合物在0.098MPa 高真空下进行乙醇回收。控制蒸馏湿度小于55℃将回收后的乙醇套用到酯化2中，然后将剩余产物用液碱进行中和，使其pH值为6-7，萃取，再蒸馏，得成品165.05g。工艺参数：三氯氧磷：乙醇=1：9（mol),反应湿度15℃反应时间为1.5h；产品收率约82%。

3.氯代磷酸二乙酯的制备　将三氯化磷与甲苯混合后，搅拌下加入无水乙醇，温度控制在30～40℃，加完后继续搅拌0.5h，反应生成亚磷酸二乙酯。接着再滴入二氯硫酰，温度控制在35℃，加完后加入无水乙醇并搅拌1h，维持温度在30～40℃，减压除去多余的二氯硫酰，剩余物即氯代磷酸二乙酯。反应式如下：

4.磷酸三乙酯的制备　将乙醇钠的醇溶液加入反应釜，在搅拌下滴加氯代磷酸二乙酯，温度控制在70℃以下，用乙醇钠和乙酸调解pH值至7～8，加完后搅拌4h。然后加入冷水，搅拌均匀后再加入甲苯，继续搅拌一段时间，静置分层，提取上层油状物，用无水碳酸钾干燥，过滤后回收甲苯，再进行减压蒸馏，收集72～88℃/0.4～0.0667MPa的产物，即得成品。该步反应式为：

磷酸三乙酯海关

[ 海关编码 ]: 29190090

磷酸三乙酯文献

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