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5,7-二氯-8-羟基喹啉

5,7-二氯-8-羟基喹啉用途

Chloroxine是合成的抗生素,对头皮屑和脂溢性皮炎有效。

5,7-二氯-8-羟基喹啉名称

[ CAS 号 ]:
773-76-2

[ 中文名 ]:
5,7-二氯-8-羟基喹啉

[ 英文名 ]:
Chloroxine

[中文别名 ]:

[英文别名 ]:

5,7-Dichloro-8-quinolinol
5,7-Dichloro-8-hydroxyquinoline
EINECS 212-258-3
Chloroxine
5,7-dichloroquinolin-8-ol
8-Quinolinol, 5,7-dichloro-
MFCD00006786

5,7-二氯-8-羟基喹啉生物活性

[ 描述 ]:

Chloroxine是合成的抗生素,对头皮屑和脂溢性皮炎有效。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. http://www.drugs.com/cons/chloroxine-topical.html

[相关活性小分子]

5,7-二氯-8-羟基喹啉物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
354.7±37.0 °C at 760 mmHg

[ 熔点 ]:
178-180 °C(lit.)

[ 分子式 ]:
C₉H₅Cl₂NO

[ 分子量 ]:
214.048

[ 闪点 ]:
168.3±26.5 °C

[ 精确质量 ]:
212.974823

[ PSA ]:
33.12000

[ LogP ]:
3.75

[ 外观性状 ]:
黄褐色结晶粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.702

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
可溶于：苯,丙酮；极微溶：氯仿,乙醇

5,7-二氯-8-羟基喹啉MSDS

5,7-二氯-8-羟基喹啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC5350000

CHEMICAL NAME :: 8-Quinolinol, 5,7-dichloro-

CAS REGISTRY NUMBER :: 773-76-2

BEILSTEIN REFERENCE NO. :: 0153606

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H5-Cl2-N-O

MOLECULAR WEIGHT :: 214.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 100 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994

5,7-二氯-8-羟基喹啉安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39-S25-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VC5350000

[ 海关编码 ]:
2933499090

5,7-二氯-8-羟基喹啉合成路线

5,7-二氯-8-羟基喹啉上下游产品

5,7-二氯-8-羟基喹啉上游产品

5,7-二氯-8-羟基喹啉下游产品

5,7-二氯-8-羟基喹啉制备

由8-羟基喹啉经氯化而得。将10g8-羟基喹啉溶于100g冰醋酸中，然后通过氯气直至溶液成为金黄色为止。将反应物注入1升水中，即析出5g7-二氯-8-羟基喹啉，过滤后用200ml丙酮重结晶而得成品。

5,7-二氯-8-羟基喹啉海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5,7-二氯-8-羟基喹啉文献

Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.

Org. Lett. 16(3) , 864-7, (2014)

A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of cop...

Reverse-phase high-performance liquid chromatographic determination of halogenated 8-hydroxyquinoline compounds in pharmaceuticals and bulk drugs.

J. Pharm. Sci. 73(10) , 1430-3, (1984)

A reverse-phase high-performance liquid chromatographic (HPLC) method was developed for determining iodochlorhydroxyquin, 5,7-dichloro-8-hydroxyquinoline, and 5,7-diiodo-8-hydroxyquinoline in creams, ...

Effects of chlorhexidine, iodine, and 5,7-dichloro-8-hydroxyquinoline on the bacterial composition of rat plaque in vivo.

Caries Res. 18(5) , 440-6, (1984)

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