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碘酸钠

碘酸钠用途

【用途一】
用作分析试剂和氧化剂，还用于制药工业
【用途二】
用于医药，用作防腐消毒剂，也可用作氧化剂
【用途三】
防腐剂、医药消毒剂。饲料添加剂。
【用途四】
用作分析试剂、氧化剂、还用于医药工业。

碘酸钠名称

[ CAS 号 ]:
7681-55-2

[ 中文名 ]:
碘酸钠

[ 英文名 ]:
Sodium iodate

[英文别名 ]:

UNII-U558PCS5Z9
EINECS 231-672-5
SODIUM IODATE
Iodic acid,sodium salt
MFCD00003533
IODIC ACID, SODIUM SALT

碘酸钠物理化学性质

[ 密度 ]:
4.28 g/mL at 25 °C(lit.)

[ 分子式 ]:
INaO₃

[ 分子量 ]:
197.892

[ 精确质量 ]:
197.878967

[ PSA ]:
57.20000

[ LogP ]:
0.52930

[ 外观性状 ]:
白色至淡黄色粉末

[ 储存条件 ]:
室温

[ 水溶解性 ]:
soluble

碘酸钠MSDS

详细MSDS(安全技术说明书)

碘酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NN1400000

CHEMICAL NAME :: Iodic acid, sodium salt

CAS REGISTRY NUMBER :: 7681-55-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: I-O3.Na

MOLECULAR WEIGHT :: 197.89

WISWESSER LINE NOTATION :: NA I-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 505 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 120,171,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 119 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 120,171,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 108 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 120,171,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 1,274,1955

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - proteinuria

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 40,451,1930 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 14,231,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84430 No. of Facilities: 222 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1620 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84430 No. of Facilities: 582 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 8972 (estimated) No. of Female Employees: 6739 (estimated)

碘酸钠安全信息

[ 符号 ]:

GHS03, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H272-H302-H317-H334

[ 警示性声明 ]:
P220-P261-P280-P342 + P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
O:Oxidizingagent;Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38;R8

[ 安全声明 (欧洲) ]:
S17-S22-S36/37-S45-S37/39-S26

[ 危险品运输编码 ]:
UN 1479 5.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
NN1400000

[ 包装等级 ]:
II

[ 危险类别 ]:
5.1

碘酸钠制备

1.电化学法：将碘化钠溶液加入电解槽进行电解氧化，制得碘酸钠溶液，经蒸发浓缩，冷却结晶，离心分离，干燥，制得碘酸钠。

2.氯酸钠氧化法：将碘和氯酸钠按一定配料比和水加入反应器中，用硝酸调节溶液Ph值为1～2，在搅拌下加热使溶液沸腾，反应完全并逐出氯气，将溶液冷却至室温，析出碘酸氢钠结晶，经过滤，将结晶用热水加热溶解后，加入苛性钠中和至溶液Ph值为10，再经冷却结晶，过滤，干燥，制得碘酸钠成品。其

3.在5L烧瓶中，于45℃把125g NaClO3溶于500mL水。加入浓硝酸2mL，碘100g，加热至反应开始。若反应混合液呈酸性则于50℃开始反应，若反应激烈可冷却烧瓶。反应结束使碘全部消失约需10～15min。加热混合液并搅拌以便氯气全部被逐出。然后用NaOH或Na2CO3水溶液中和使碘酸钠结晶析出，冷却，过滤。约得85g碘酸钠，将粗品溶于3.5倍热水重结晶精制。 4.在20%的氯酸钠水溶液中加入适量浓硝酸和碘进行反应。开始缓慢加热至反应激烈时，外部用水冷却：

碘全部反应完后，所得碘酸钠及其酸式盐的混合溶液进行加热，不断搅拌直至氯气全部逸出，再用碳酸钠溶液中和，使碘酸钠结晶析出：

冷却后过滤，所得结晶用3.5倍的热水溶解，进行重结晶，并于150℃干燥，即得试剂碘酸钠。

碘酸钠文献

Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.

Nat. Commun. 5 , 3793, (2014)

Myogenic regulatory factors such as MyoD and Myf5 lie at the core of vertebrate muscle differentiation. However, E-boxes, the cognate binding sites for these transcription factors, are not restricted ...

Resveratrol protects RPE cells from sodium iodate by modulating PPARα and PPARδ.

Exp. Eye Res. 118 , 100-8, (2014)

Selective killing of RPE cells in vivo by sodium iodate develops cardinal phenotypes of atrophic age-related macular degeneration. However, the molecular mechanisms are elusive. We tried to search for...

H9 Inhibits Tumor Growth and Induces Apoptosis via Intrinsic and Extrinsic Signaling Pathway in Human Non-Small Cell Lung Cancer Xenografts.

J. Microbiol. Biotechnol. 25 , 648-57, (2015)

H9, a novel herbal extract, demonstrated cytotoxicity in A549 non-small cell lung cancer (NSCLC) cell lines. In this study, we investigated whether H9, and/or co-treatment with an anticancer drug, pem...

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碘酸钠