4-Hydroxyphenyl-dimethyl-phenylsilan

4-Hydroxyphenyl-dimethyl-phenylsilan用途

雌激素受体-IN-1(化合物16)是一种有效的雌激素受体(ER)抑制剂,ERα和ERβ的IC50分别为13,5µM[1]。

4-Hydroxyphenyl-dimethyl-phenylsilan名称

[ CAS 号 ]:
74027-99-9

[ 英文名 ]:
4-Hydroxyphenyl-dimethyl-phenylsilan

[英文别名 ]:

4-phenyldimethylsilylphenole

4-Hydroxyphenyl-dimethyl-phenylsilan生物活性

[ 描述 ]:

雌激素受体-IN-1(化合物16)是一种有效的雌激素受体(ER)抑制剂,ERα和ERβ的IC50分别为13,5µM[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 代谢疾病

[ 靶点 ]

ERα:13 μM (IC50)

ERβ:5 μM (IC50)

[参考文献]

[1]. Saito H, et al. Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives. Bioorg Med Chem. 2020 Feb 15;28(4):115310.

4-Hydroxyphenyl-dimethyl-phenylsilan物理化学性质

[ 分子式 ]:
C₁₄H₁₆OSi

[ 分子量 ]:
228.36200

[ 精确质量 ]:
228.09700

[ PSA ]:
20.23000

[ LogP ]:
2.21480

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相关化合物

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标题：【4-Hydroxyphenyl-dimethyl-phenylsilan】4-Hydroxyphenyl-dimethyl-phenylsilan CAS号:74027-99-9【结构式性质活性】-化源网地址：https://www.chemsrc.com/amp/cas/74027-99-9_438550.html