17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one

用途

DMAA 是一种间接拟交感胺, 能收缩血管和升高血压。DMAA 可用于神经和心血管疾病的研究。

名称

[ CAS 号 ]:
73671-86-0

[ 英文名 ]:
17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one

生物活性

[ 描述 ]:

DMAA 是一种间接拟交感胺, 能收缩血管和升高血压。DMAA 可用于神经和心血管疾病的研究。

[ 相关类别 ]:

研究领域 >> 心血管疾病
研究领域 >> 神经疾病

[参考文献]

[1]. Rodricks JV, et al. DMAA as a dietary ingredient. JAMA Intern Med. 2013 Apr 8;173(7):594-5.

[2]. Richard J Bloomer, et al. 1,3-Dimethylamylamine (DMAA): A Brief History and Review of Anecdotal and Laboratory Findings. J Altern Complement Integr Med. 2018 Dec 28.

物理化学性质

[ 密度 ]:
1.051g/cm3

[ 沸点 ]:
528.3ºC at 760 mmHg

[ 分子式 ]:
C24H40N2O2

[ 分子量 ]:
388.59

[ 闪点 ]:
209.8ºC

[ 精确质量 ]:
388.30900

[ PSA ]:
40.62000

[ LogP ]:
4.27230

[ 折射率 ]:
1.519

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CL5200000
CHEMICAL NAME :
5-alpha-4-Azaandrostane-17-beta-carboxamide, N,N-diethyl-4-methyl-3-oxo-
CAS REGISTRY NUMBER :
73671-86-0
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C24-H40-N2-O2
MOLECULAR WEIGHT :
388.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2100 mg/kg
SEX/DURATION :
male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,67,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
700 mg/kg
SEX/DURATION :
male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,67,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
135 mg/kg
SEX/DURATION :
female 13-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,67,1982

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