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苏马佐

苏马佐用途

舒马唑是一种强心剂。Sulmazole对A1腺苷受体具有竞争性抑制作用。舒马唑可以改善心脏指数并降低肺毛细血管楔压[1]。

苏马佐名称

[ CAS 号 ]:
73384-60-8

[ 中文名 ]:
苏马佐

[ 英文名 ]:
Sulmazole

[中文别名 ]:

[英文别名 ]:

苏马佐生物活性

[ 描述 ]:

舒马唑是一种强心剂。Sulmazole对A1腺苷受体具有竞争性抑制作用。舒马唑可以改善心脏指数并降低肺毛细血管楔压[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病
信号通路 >> 其他 >> 其他

[体外研究]

Sulmazole对A1腺苷受体具有竞争性抑制作用[1]。Sulmazole减弱GTP抑制腺苷酸环化酶活性的能力,百日咳毒素治疗对Gi的共价修饰消除了Sulmazol介导刺激的能力[1]。Sulmazole对百日咳毒素处理的膜中的腺苷酸环化酶活性具有刺激作用[1]。Sulmazole通过除磷酸二酯酶抑制以外的机制介导cAMP积累的增加,包括A1腺苷受体拮抗和Gi功能的抑制[1]。

苏马佐物理化学性质

[ 密度 ]:
1.45g/cm3

[ 沸点 ]:
577.7ºC at 760 mmHg

[ 分子式 ]:
C14H13N3O2S

[ 分子量 ]:
287.33700

[ 闪点 ]:
303.2ºC

[ 精确质量 ]:
287.07300

[ PSA ]:
87.08000

[ LogP ]:
3.23660

[ 折射率 ]:
1.722

苏马佐MSDS

详细MSDS(安全技术说明书)

苏马佐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ5749500
CHEMICAL NAME :
1H-Imidazo(4,5-b)pyridine, 2-(2-methoxy-4-(methylsulfinyl)phenyl)-
CAS REGISTRY NUMBER :
73384-60-8
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C14-H13-N3-O2-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,226,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
91 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,226,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
560 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Behavioral - antipsychotic Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,141,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
163 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Behavioral - antipsychotic Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,141,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,226,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,226,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,226,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2940 mg/kg/14W-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects Cardiac - other changes Related to Chronic Data - death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,226,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
980 mg/kg/4W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,226,1981

苏马佐安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
26-36

推荐生产厂家/供应商：

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Sulmazole

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1354.0/50mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

产品详情：苏咪唑

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苏马佐供应商

相关化合物

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