氟苯尼考

氟苯尼考用途

Florfenicol是一种常见得兽用抗生素,能够治疗牛呼吸疾病,在水产养殖业中可以用来控制鲶鱼肠道败血病,同时可以诱导鸡蛋早期胚胎死亡,LC50值为1.07 μg/g。

氟苯尼考作用

氟苯尼考通过与细菌核糖体上的50S亚基紧密结合，阻碍肽酰基转移酶的转肽反应，从而抑制肽链的延伸；同时选择性地作用于组成细菌菌体的70S核蛋白体的受体，改变和干扰肽酰转移酶的功能，从而双重干扰细菌蛋白质的合成。抗生素类药物，通过抑制肽酰基转移酶活性而产生广谱抑菌作用，抗菌谱广，包括各种革兰氏阳性、阴性菌
和支原体等。敏感菌包括牛、猪的嗜血杆菌、痢疾志贺氏菌、沙门氏菌、大肠杆菌、肺炎球菌、流感杆菌、
链球菌、金黄色葡萄球菌、衣原体、钩端螺旋体，立克次氏体等。

氟苯尼考名称

[ CAS 号 ]:
73231-34-2

[ 中文名 ]:
氟苯尼考

[ 英文名 ]:
Florfenicol

[中文别名 ]:

[英文别名 ]:

Florfenicol
NUFLOR
2,2-dichloro-N-[(1S
AQUAFEN
Fluorothiamphenicol
2,2-DIBROMODECAFLUOROPENTANE
Florfeniol
Aquaflor
MFCD00864834
EINECS 642-986-0

氟苯尼考生物活性

[ 描述 ]:

Florfenicol是一种常见得兽用抗生素,能够治疗牛呼吸疾病,在水产养殖业中可以用来控制鲶鱼肠道败血病,同时可以诱导鸡蛋早期胚胎死亡,LC50值为1.07 μg/g。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11(1):213.

[2]. Corinna Kehrenberg, et al. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Molecular Microbiology Volume 57, Issue 4, pages 1064–1073, August 2005

[相关活性小分子]

氟苯尼考物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
617.5±55.0 °C at 760 mmHg

[ 熔点 ]:
153 °C

[ 分子式 ]:
C₁₂H₁₄Cl₂FNO₄S

[ 分子量 ]:
358.213

[ 闪点 ]:
327.3±31.5 °C

[ 精确质量 ]:
357.000458

[ PSA ]:
91.85000

[ LogP ]:
-0.12

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.548

[ 储存条件 ]:
0-6°C

氟苯尼考MSDS

详细MSDS(安全技术说明书)

氟苯尼考毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB6034000

CHEMICAL NAME :: Benzenesulfonic acid, 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl )-, methyl ester, (R-(R*,S*))-

CAS REGISTRY NUMBER :: 73231-34-2

LAST UPDATED :: 198806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H11-Cl2-F-N2-O4

MOLECULAR WEIGHT :: 325.14

WISWESSER LINE NOTATION :: WNR DYQY1FMVYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,172,1982

氟苯尼考安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2930909090

氟苯尼考合成路线

详细合成路线

氟苯尼考上下游产品

氟苯尼考上游产品

氟苯尼考下游产品

氟苯尼考海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

氟苯尼考文献

Multiresidue method for the determination of pharmacologically active substances in egg and honey using a continuous solid-phase extraction system and gas chromatography-mass spectrometry.

Food Chem. 178 , 63-9, (2015)

A sensitive, selective, efficient gas chromatography-mass spectrometry method for the simultaneous determination of 22 pharmacologically active substances (antibacterials, nonsteroidal antiinflammator...

Development and validation of determinative and confirmatory LC-MS/MS methodologies for total florfenicol and tulathromycin residues in bovine, equine and porcine kidney, liver and muscle tissues.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 1-9, (2015)

Separate methods for the quantitation and confirmation of regulatory relevant residue concentrations of total florfenicol and tulathromycin residues in multiple tissue matrices were developed and vali...

Preparation and evaluation of poly(alkyl methacrylate-co-methacrylic acid-co-ethylene dimethacrylate) monolithic columns for separating polar small molecules by capillary liquid chromatography.

Anal. Chim. Acta 871 , 57-65, (2015)

In this study, methacrylic acid (MAA) was incorporated with alkyl methacrylates to increase the hydrophilicity of the synthesized ethylene dimethacrylate-based (EDMA-based) monoliths for separating po...

更多文献