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STF-31

STF-31用途

STF-31 是一种葡萄糖转运1抑制剂 (GLUT1, IC50 = 1 μM)。

STF-31名称

[ CAS 号 ]:
724741-75-7

[ 中文名 ]:
STF-31

[ 英文名 ]:
STF 31

[英文别名 ]:

2HJ
QC-5204
STF-31

STF-31生物活性

[ 描述 ]:

STF-31 是一种葡萄糖转运1抑制剂 (GLUT1, IC50 = 1 μM)。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 癌症

[参考文献]

[1]. Chan DA, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 2011 Aug 3;3(94):94ra70.

[2]. Liu Y, et al. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, andinhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther. 2012 Aug;11(8):1672-1682.

[相关活性小分子]

STF-31物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 分子式 ]:
C₂₃H₂₅N₃O₃S

[ 分子量 ]:
423.528

[ 精确质量 ]:
423.161652

[ PSA ]:
96.54000

[ LogP ]:
3.88

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.612

[ 储存条件 ]:
-20℃

STF-31MSDS

详细MSDS(安全技术说明书)

STF-31安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危险品运输编码 ]:
NONH for all modes of transport

STF-31文献

A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression.

Biochim. Biophys. Acta 1847 , 1254-66, (2015)

Abnormal accumulation of oncometabolite fumarate and succinate is associated with inhibition of mitochondrial function and carcinogenesis. By competing with α-ketoglutarate, oncometabolites also activ...

NAMPT is the cellular target of STF-31-like small-molecule probes.

ACS Chem. Biol. 9(10) , 2247-54, (2014)

The small-molecule probes STF-31 and its analogue compound 146 were discovered while searching for compounds that kill VHL-deficient renal cell carcinoma cell lines selectively and have been reported ...

Glucose is a key driver for GLUT1-mediated nanoparticles internalization in breast cancer cells.

Sci. Rep. 6 , 21629, (2016)

The mesenchymal state in cancer is usually associated with poor prognosis due to the metastatic predisposition and the hyper-activated metabolism. Exploiting cell glucose metabolism we propose a new m...

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