1-甲基尿酸

1-甲基尿酸用途

1-Methyluric acid 作用于膀胱黏膜,并能增加血糖,胰岛素,甘油三酯和胆固醇的水平。

1-甲基尿酸名称

[ CAS 号 ]:
708-79-2

[ 中文名 ]:
1-U 1-甲基-2,6,8-三羟基嘌呤 1MUA

[ 英文名 ]:
1-Methyluric acid

[中文别名 ]:

1-甲基尿酸

[英文别名 ]:

1-methyl-8-oxyxanthine
1-Methyluric acid
1-Methylurate
1MUA
1-methyl-7,9-dihydro-3H-purine-2,6,8-trione
1-Methyl-2,6,8-trihydroxypurine
1-Methyl-harnsaeure

1-甲基尿酸生物活性

[ 描述 ]:

1-Methyluric acid 作用于膀胱黏膜,并能增加血糖,胰岛素,甘油三酯和胆固醇的水平。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体内研究]

与用蒸馏水灌注膀胱相比,用1-甲基尿酸溶液灌注膀胱显示血清总胆固醇水平,真甘油三酯水平,葡萄糖水平和胰岛素水平增加[1]。

[动物实验]

大鼠[1]将体重为200-300g大鼠的任一性别的Wistar品系的成年白化大鼠用于本研究。将30只白化大鼠分成三组，每组10只。组I用作用蒸馏水灌注的对照组。插管后，用蒸馏水灌注膀胱。第II组用作尿酸灌注组。 III组用作1-甲基尿酸灌注组。除了使用1-甲基尿酸（0.0024 g / 100 mL）水溶液代替蒸馏水灌注膀胱外，对照组的动物以与对照组（第I组）类似的方式进行治疗[1] 。

[参考文献]

[1]. Balasubramanian T, et al. Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats. ScientificWorldJournal. 2003 Oct 5;3:930-6.

[相关活性小分子]

1-甲基尿酸物理化学性质

[ 密度 ]:
1.73g/cm3

[ 沸点 ]:
315.51°C (rough estimate)

[ 熔点 ]:
>325ºC

[ 分子式 ]:
C₆H₆N₄O₃

[ 分子量 ]:
182.13700

[ 精确质量 ]:
182.04400

[ PSA ]:
103.51000

[ 折射率 ]:
1.695

[ 储存条件 ]:
Refrigerator

1-甲基尿酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

1-甲基尿酸合成路线

详细合成路线

1-甲基尿酸上下游产品

1-甲基尿酸上游产品

1-甲基尿酸下游产品

1-甲基尿酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-甲基尿酸文献

Altered age-related changes in bioenergetic properties and mitochondrial morphology in fibroblasts from sporadic amyotrophic lateral sclerosis patients.

Neurobiol. Aging 36 , 2893-903, (2015)

Mitochondria play a key role in aging, which is a well-established risk factor in amyotrophic lateral sclerosis (ALS). We have previously modeled metabolic dysregulation in ALS using fibroblasts isola...

Pyogranulomatous pneumonia in goats caused by an undescribed Porphyromonas species, "Porphyromonas katsikii".

J. Clin. Microbiol. 53(3) , 795-8, (2015)

A yet-undescribed bacterial species, tentatively named "Porphyromonas katsikii," was isolated from individuals of a small goat herd with pyogranulomatous pneumonia during an outbreak of acute respirat...

Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?

Eur. J. Clin. Pharmacol. 65(4) , 411-7, (2009)

Individual activities of N-acetyltransferase 2 (NAT2) and of xanthine oxidase (XO) can be assessed using ratios of urinary caffeine metabolites. We investigated how ratios changed over time and which ...

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