色霉素A3
色霉素A3用途
色霉素A3名称
[ CAS 号 ]:
7059-24-7
[ 中文名 ]:
色霉素A3
[ 英文名 ]:
Chromomycin A3
[中文别名 ]:
[英文别名 ]:
- MFCD00043151
- Chromoycin A3
- antibioticb599
- EINECS 230-348-0
- TOYOMYCIN
- Olivomycin D
- CHROMOMYCIN A3
- Chromomycin
- aburamycinb
色霉素A3生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
色霉素A3物理化学性质
[ 密度 ]:
1.43g/cm3
[ 沸点 ]:
1147.6ºC at 760 mmHg
[ 熔点 ]:
185℃
[ 分子式 ]:
C57H82O26
[ 分子量 ]:
1183.25000
[ 闪点 ]:
311.1ºC
[ 精确质量 ]:
1182.51000
[ PSA ]:
359.34000
[ LogP ]:
1.54640
[ 外观性状 ]:
黄色粉末
[ 折射率 ]:
1.608
[ 储存条件 ]:
2-8°C,避光
色霉素A3毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GB7875000
- CHEMICAL NAME :
- Chromomycin A3
- CAS REGISTRY NUMBER :
- 7059-24-7
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 28
- MOLECULAR FORMULA :
- C57-H82-O26
- MOLECULAR WEIGHT :
- 1183.39
- WISWESSER LINE NOTATION :
- L C666 DVT&&J BQ FYO1&VYQYQ1 M1 NQ LO- BT6OTJ DOV1 F1 EO- BT6OTJ DQ EO1 F1&& EO- BT6OTJ EQ F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1431 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 200 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - coma Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 330 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - coma Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 500 ug/kg/5D-I
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Blood - other changes Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 750 ug/kg/5D-I
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Liver - fatty liver degeneration Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 250 ug/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 125 ug/kg
- SEX/DURATION :
- female 6-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 500 ug/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 125 ug/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,2813,1985 *** REVIEWS *** TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965
色霉素A3安全信息
[ 符号 ]:
GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H300-H360
[ 警示性声明 ]:
P201-P264-P301 + P310-P308 + P313
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T+,T
[ 风险声明 (欧洲) ]:
61-28
[ 安全声明 (欧洲) ]:
S28;S45;S53;S36/S37/S39
[ 危险品运输编码 ]:
UN 3462 6.1/PG 1
[ WGK德国 ]:
3
[ RTECS号 ]:
GB7875000
[ 包装等级 ]:
I
[ 危险类别 ]:
6.1(a)
色霉素A3文献
Cytogenet. Genome Res. 142(1) , 46-53, (2014)
Heteroptera is the most numerous and diverse suborder of Hemiptera, with about 38,000 species. This diversity also involves cytogenetic features, including chromosome number and a sex determining syst...
Association of aureolic acid antibiotic, chromomycin A3 with Cu2+ and its negative effect upon DNA binding property of the antibiotic.Biometals 25(2) , 435-50, (2012)
Here we have examined the association of an aureolic acid antibiotic, chromomycin A3 (CHR), with Cu(2+). CHR forms a high affinity 2:1 (CHR:Cu(2+)) complex with dissociation constant of 0.08 × 10(-10)...
Evaluation of sperm's chromatin quality with acridine orange test, chromomycin A3 and aniline blue staining in couples with unexplained recurrent abortion.J. Assist. Reprod. Genet. 26(11-12) , 591-6, (2009)
To evaluate the sperm's chromatin quality in couples with spontaneous recurrent abortion.Thirty couples with spontaneous recurrent abortion (case group) and 30 fertile couples (control group) referrin...
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公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥591.0/1mg
¥1773.0/5mg
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:Chromomycin A3
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区域:韶关市翁源县
价格:
¥2000.0/1mg
联系人:朱丽丹
产品详情:色霉素A3
公司名:上海陌孚医药科技有限公司
区域:上海市嘉定区
价格:
¥706.5/1mg
¥1746.0/5mg
联系人:朱经理
产品详情:色霉素A3
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相关化合物
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