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乙二醇-双(琥珀酸N-羟基琥珀酰亚胺酯)

乙二醇-双(琥珀酸N-羟基琥珀酰亚胺酯)用途

EGNHS 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。

乙二醇-双(琥珀酸N-羟基琥珀酰亚胺酯)名称

[ CAS 号 ]:
70539-42-3

[ 中文名 ]:
乙二醇-双(丁二酸 N-羟基琥珀酰亚胺酯)

[ 英文名 ]:
EGNHS

[中文别名 ]:

[英文别名 ]:

EGS
MFCD00049057
Peg-SS
EGBSS

乙二醇-双(琥珀酸N-羟基琥珀酰亚胺酯)生物活性

[ 描述 ]:

EGNHS 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl/ether

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

乙二醇-双(琥珀酸N-羟基琥珀酰亚胺酯)物理化学性质

[ 密度 ]:
1.52g/cm3

[ 沸点 ]:
603.4ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₂₀N₂O₁₂

[ 分子量 ]:
456.35800

[ 闪点 ]:
318.7ºC

[ 精确质量 ]:
456.10200

[ PSA ]:
179.96000

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.56

[ 储存条件 ]:
2-8°C，干燥，密封，惰性气体

乙二醇-双(琥珀酸N-羟基琥珀酰亚胺酯)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

乙二醇-双(琥珀酸N-羟基琥珀酰亚胺酯)文献

Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1.

Oncotarget 6 , 36338-53, (2015)

The mitochondrial accumulation of ATF2 is involved in tumor suppressor activities via cytochrome c release in melanoma cells. However, the signaling pathways that connect mitochondrial ATF2 accumulati...

Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia.

Epigenetics Chromatin 8 , 53, (2015)

Precise nucleosome positioning is an increasingly recognized feature of promoters and enhancers, reflecting complex contributions of DNA sequence, nucleosome positioning, histone modification and tran...

Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.

J. Biol. Chem. 290 , 28329-42, (2015)

Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target genes. Here, we report that transcriptional ...

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